BACKGROUND Evaluation of the collection efficiencies of ion chambers is a necessity for the proper evaluation of radiation quantities in different applications. Overall collection efficiency is the product of three different values: collection efficiencies considering contributions of, volume recombination, back-diffusion loss and initial recombination, the later may be neglected at low charge ...

We report, for the first time, a direct, atomic-scale characterization of Pb in zircon (4.4–3.1 Ga) from the early Archean Yilgarn craton in Australia using high-resolution HAADF-STEM. Two forms of Pb have been identified: Pb concentrated at 3 atom% as a nanoscale patch in zircon structure, and Pb concentrated within the amorphous domain created by fission fragment damage. The first result sugg...

BACKGROUND high-altitude adaptation leads to progressive increase in arterial Pa(O2). In addition to increased ventilation, better arterial oxygenation may reflect improvements in lung gas exchange. Previous investigations reveal alterations at the alveolar-capillary barrier indicative of decreased resistance to gas exchange with prolonged hypoxia adaptation, but how quickly this occurs is unkn...

Background: Presurigical planning for glioma tumor resection and radiotherapy treatment require proper delineation of tumoral and peritumoral areas of brain. Diffusion tensor imaging (DTI) is the most common mathematical model applied for diffusion weighted MRI data. Neurite orientation dispersion and density imaging (NODDI) is another mathematical model for DWI data modeling.Objective: We stud...

In the brain-cell microenvironment, the movement of ions is by diffusion when there is not any electrical activity in either the cells or the externally applied electric field. In this complex medium, the primary constraints on long-range diffusion are due to the geometrical properties of the medium, especially tortuosity and volume fraction, which are lumped parameters that incorporate local g...

PURPOSE A new approach has been developed to quantify cell sizes and intracellular volume fractions using temporal diffusion spectroscopy with diffusion-weighted acquisitions. METHODS Temporal diffusion spectra may be used to characterize tissue microstructure by measuring the effects of restrictions over a range of diffusion times. Oscillating gradients have been used previously to probe var...

BACKGROUND AND PURPOSE The pathogenesis of cerebral venous infarction (CVI) remains controversial, with uncertainty over whether cytotoxic edema plays a role. Recent animal studies have shown that cytotoxic edema reliably occurs in acute CVI and precedes the onset of vasogenic edema. Our hypothesis was that cytotoxic edema would also occur in acute human CVI and would be detectable as an area o...

The rate constants for diffusion of THO across the red cell membrane of beef and dog, and the rate of entrance of water into the erythrocytes of these species under an osmotic pressure gradient have been measured. For water entrance into the erythrocyte by diffusion the rate constants are 0.10 +/- 0.02 msec.(-1) (beef) and 0.14 +/- 0.03 msec.(-1) (dog); the permeability coefficients for water e...

OBJECTIVE/BACKGROUND The majority of multiple sclerosis patients experience impaired walking ability, which impacts quality of life. Timed 25-foot walk is commonly used to gauge gait impairment but results can be broadly variable. Objective biological markers that correlate closely with patients' disability are needed. Diffusion tensor imaging, quantifying fiber tract integrity, might provide s...

Although synaptic transmission is an important means of communication between neurons, neurons themselves and neurons and glia also communicate by extrasynaptic "volume" transmission, which is mediated by diffusion in the extracellular space (ECS). The ECS of the central nervous system (CNS) is the microenvironment of neurons and glial cells. The composition and size of ECS change dynamically d...