Taxol is a promising agent for use in ovarian cancer and other malignancies. One problem associated with taxol is its low aqueous solubility, requiring Cremophor EL (polyethoxylated castor oil) and ethanol as excipients (Diluent 12); these agents cause serious adverse effects. Liposomes containing taxol and phospholipid (in a 1:33 mole ratio, respectively) were prepared from phosphatidylglycero...

A unique clinical chemistry analyser is described which processes 90 mul of whole blood (fingerstick or venous) into multiple aliquots of diluted plasma and reports the results of 12 tests in 14 min. To perform a panel of tests, the operator applies the unmetered sample directly into a single use, 8 cm diameter plastic rotor which contains the required liquid diluent and dry reagents. Using cen...

Various dieldrin water-dispersible powder formulations have been subjected to elevated temperature storage and the effect on their suspensibilities compared. The Shell Chemical Company's 50% dieldrin formulation AC 1630 was recommended for use in the malaria control programmes of the International Cooperation Administration rather than its 50% formulation AC 1631, on the basis of superior perfo...

15-hydroxyeicosatetraenoic acid (15-HETE) is the predominant oxidative metabolite of arachidonic acid in human lung. We have studied its effects on airway calibre and non-specific bronchial responsiveness (NSBR) in eight normal and eight asthmatic subjects. 15-HETE, at doses up to 70 nmol, had no effect on airway calibre in either group of subjects. However, 3 h after its administration, 15-HET...

Optimization of performance of holographic gratings was investigated by changing the chemical structures of photopolymerizable monomers, the LC content, and recording beam intensity, which strongly related to the control of kinetics of polymerization and phase separation of LCs. High diffraction efficiency was obtained using 3-acryloxypropyltrimethoxysilane (APTMS) and 2-[(3,4-epoxycyclohexyl)e...

This paper describes separate spectrophotometric procedures for rapidly measuring carboxyhemoglobin (COHb) and methemoglobin (MetHb) in blood. Absorbance measurements are made in the Soret region at a blood dilution near 1000-fold. For COHb estimation, the diluent contains sodium hydrosulfite, providing the two-component system COHb--Hb for absorbance measurements at 420 and 432 nm. The NA2S2O4...

It has been suggested that haemodilution with saline may increase whole blood coagulation. This study was conducted in two parts. First, we investigated the effect of in vitro dilution of blood with saline on whole blood coagulation as measured by the thrombelastogram (TEG). Blood (4 ml) was diluted with 0.9% saline 1 ml and coagulation compared with that of an undiluted control specimen obtain...

A routine utilization review of our assay of high-density-lipoprotemn (HDL) cholesterol with a centrifugal analyzer (1) indicated that efficiency might be improved by an alternative HDL cholesterol method requiring less dedicated technologist time. The relatively few requests, coupled with our physicians’ expectation for turnaround, dictated that we could not use the centrifugal analyzer method...

A questionnaire was sent to physicians with an interest in chest disease to determine the dose and method of delivery of nebulised beta agonists in hospital. All of the 67 physicians replying gave beta agonists by nebuliser, and all reported either salbutamol (72%) or terbutaline (10%) as the drug they prescribed most commonly (18% gave either drug). There was a fivefold difference in the dose ...