NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associate...

The advent of three-dimensional printing (3DP) technology has enabled the creation of a tangible and complex 3D object that goes beyond a simple 3D-shaded visualization on a flat monitor. Since the early 2000s, 3DP machines have been used only in hard tissue applications. Recently developed multi-materials for 3DP have been used extensively for a variety of medical applications, such as persona...

We consider the planar pendulum with support point oscillating in the vertical direction, and we study its motion around the equilibrium point corresponding to the upside-down position. We prove that the equilibrium point is stable for the projection of the motion on the pendulum phase space (for a full measure subset of the stability region of the linearized system inside the two-dimensional s...

In this paper, a fully Bayesian approach to articulated human motion tracking from video sequences is presented. First, a ltering procedure with a low-dimensional manifold is derived. Next, we propose a general framework for approximating this ltering procedure based on the particle lter technique. The low-dimensional manifold can be treated as a regularizer which restricts the space of all pos...

We show how some features of the AdS/CFT correspondence for AdS3 can easily be understood via standard world-sheet methods and 2d gravity like scaling arguments. To do this, we propose a stringy way for perturbing two-dimensional CFT’s around their critical points. Our strategy is to start from a stringy (world-sheet) representation of 2d CFT in space-time. Next we perturb a world-sheet action ...

We describe a rapid algorithm for visualizing large chemical databases in a low-dimensional space (2D or 3D) as a rst step in chemical database analyses and drug design applications. The compounds in the database are described as vectors in the high-dimensional space of chemical descriptors. The algorithm is based on the singular value decomposition (SVD) combined with a minimization procedure ...

Health professionals are faced with challenges when they have to exploit the semantics of concepts present in clinical terminologies in support of research activities. The difficulty lies in the fact that this semantics is represented not only through the labels of concepts, but also their position in the hierarchy, and, when available, their logical and textual definitions. We investigate and ...