Epithelial-like cells from rat liver were exposed in cell culture to aflatoxin BI, dimethylnitrosamine, 7V-nitrosomethylurea, jV-hydroxy-Af-2-fluorenylacetamide, or 7,12dimethylbenz(a)anthracene. Microscopic observation revealed several morphological changes in almost all of the treated sublines but revealed no uniform, characteristic alterations common to all of the cultures. The injection of ...

chemistry Nitrosamines (NAs) are a family of chemical compounds discovered over 100 years ago. It was not until the 1950s that these compounds received worldwide attention. In the 1950s, two British scientists, Barnes and Magee discovered that dimethylnitrosamine is a powerful carcinogen in laboratory animals. This finding led to massive studies involving NAs in many industries throughout the y...

Twelve common drugs that are tertiary amines react with nitrite in aqueous solution at ph 3 to 4 to form dialkylnitrosamines that are known carcinogens. Aminopyrine gave dimethylnitrosamine in 30% yield or higher at all concentra tions down to 50 ppm (with 25 ppm nitrite); the other product of this reaction was the nitrite salt of 4-hydroxyantipyrine. The other drugs, when present at 0.01 Mwith...

The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine were also found to bind to both cellular DNA and protein. Bronchial DNA...

Twelve common drugs that are tertiary amines react with nitrite in aqueous solution at ph 3 to 4 to form dialkylnitrosamines that are known carcinogens. Aminopyrine gave dimethylnitrosamine in 30% yield or higher at all concentra tions down to 50 ppm (with 25 ppm nitrite); the other product of this reaction was the nitrite salt of 4-hydroxyantipyrine. The other drugs, when present at 0.01 Mwith...