نتایج جستجو برای: dio2 gene

تعداد نتایج: 1141419  

2008
Josef Köhrle

3-iodothyronamine (3-T1AM) and thyronamine (T0AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T3) actions. The present study investigated whether thyronamines (TAMs) are substrates of the three Dio isozymes (Dio1, Dio2 and Dio3). TAMs were incubated with isozyme specific Dio preparatio...

Journal: :Hypertension 2008
Ana Luiza Maia Shih-Jen Hwang Daniel Levy Martin G Larson P Reed Larsen Caroline S Fox

Lack of Association Between the Type 2 Deiodinase A/G Polymorphism and Hypertensive Traits: The Framingham Heart Study To the Editor: Thyroxine (T4) activation to T3 via the iodothyronine deiodinase type 2 allows for changes in intracellular thyroid status in a tissue-specific manner independent of serum T3. A single nucleotide polymorphism in type 2 deodinase (DIO2) gene (A/G) in humans, in wh...

2017
Ebrahim Aboualizadeh Owen T. Carmichael Ping He Diana C. Albarado Christopher D. Morrison Carol J. Hirschmugl

Stimulating increased thermogenic activity in adipose tissue is an important biological target for obesity treatment, and label-free imaging techniques with the potential to quantify stimulation-associated biochemical changes to the adipose tissue are highly sought after. In this study, we used spatially resolved Fourier transform infrared (FTIR) imaging to quantify biochemical changes caused b...

2015
Alexander W. Ross Laura Russell Gisela Helfer Lynn M. Thomson Matthew J. Dalby Peter J. Morgan

In this study the effects of photoperiod and diet, and their interaction, were examined for their effects on growth and body composition in juvenile F344 rats over a 4-week period. On long (16L:8D), relative to short (8L:16D), photoperiod food intake and growth rate were increased, but percentage adiposity remained constant (ca 3-4%). On a high fat diet (HFD), containing 22.8% fat (45% energy a...

2017
Klaus N. Fontes Adriana Cabanelas Flavia F. Bloise Cherley Borba Vieira de Andrade Luana L. Souza Marianna Wilieman Isis H. Trevenzoli Lais C. Agra Johnatas D. Silva Christianne Bandeira-Melo Pedro L. Silva Patricia R. M. Rocco Tania M. Ortiga-Carvalho

Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the tissue level. Moreover, even though it has been considered the same syndrome, we hypothesized tha...

Journal: :Entramado 2021

Introducción: El correcto funcionamiento del eje hipotálamo-hipófisis-tiroides es indispensable para el crecimiento y desarrollo embrionario-fetal, al intervenir en la diferenciación de los tejidos, cerebral somático, maduración ósea regulación metabolismo. paso las hormonas tiroideas maternas feto a través placenta depende transportadores transmembrana, enzimas desyodinasas (DIO2 DIO3) proteín...

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