The predominantly beta-anomer of diosgenin glucoside (DG) was synthesized and its effects on cholesterol homeostasis were tested in monkeys. Cynomolgus macaques (Macaca fascicularis) were fed, during two 3-week periods, a semipurified diet with 0.1% cholesterol and a similar ration containing 1% DG, respectively. A Chow diet was given for 5 weeks between the experimental periods. Cholesterol an...

Corona Virus Disease (COVID-19) is announced as pandemic by World Health Organization (WHO) since 11th March 2020. Riau Province has many herbal plants e.g. Cheilocostus specious, Euphorbia hirta l, Cassia torra, Bryophyllum pinnatum, Daniella ensifollia, and Ziziphus mauritiana that can cure diseases there not report yet focusing on in-silico method using SARS-CoV-2 protease (PDB ID:6LU7). Thi...

The title steroid, C34H50O6S, is an inter-mediate on the synthetic route between diosgenin and brassinosteroids, which possess the A ring modified with the 2α,3α-diol functionality. The polycyclic spiro-stan system has the expected conformation, with six-membered rings adopting chair forms and the five-membered rings envelope forms (flap atoms are the methine C atom in the C/D-ring junction and...

Plant endophytic fungi are an important and novel resource of natural bioactive compounds with their potential applications in agriculture, medicine and food industry. In the past two decades, many valuable bioactive compounds with antimicrobial, insecticidal, cytotoxic and anticancer activities have been successfully discovered from the endophytic fungi. During the long period of co-evolution,...

fenugreek (trigonella foenum-graecum l.), wild or cultivated, is widely distributed throughout the world and belongs to the fabacecae family. it is an old medicinal plant and has been commonly used as a traditional food and medicine. fenugreek is known to have hypoglycemic, and hypocholesterolaemic, effects. recent research has identified fenugreek as a valuable medicinal plant with potential f...

Fenugreek (Trigonella foenum-graecum L.) is an annual forage legume and an important aromatic medicinal plant that is commercially used as spices in major parts of the world. The plant is known for its superior qualities of pharmaceutically and nutraceutically rich in several phytochemicals including several important complex carbohydrates, amino acids, steroids and saponins. The commercial ext...

Dioscorea species is a very important food and drug plant. The tubers of the plant are extensively used in food and drug purposes owing to the presence of steroidal constituent's diosgenin in the tubers. In the present study, we report for the first time that the leaves of Dioscorea composita and Dioscorea floribunda grown under the field conditions exhibited the presence of multicellular oil g...