Histamine H1 receptors mediate activation of phospholipase C, with subsequent increases in cytosolic Ca2+ concentration ([Ca2+]i), and H2 receptors mediate accumulation of cAMP. HL-60 promyelocytes possess H2 receptors, but it is not known whether these cells also possess H1 receptors. We studied the effects of histamine on [Ca2+]i and the functional importance of histamine receptors in HL-60 p...

A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1:1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional solvent at high temperature gives the target compound directly as a molten salt (ionic liquid above 168 °C...

OBJECTIVE To compare the efficacy of dapsone, diphenhydramine, colchicine, and intralesional triamcinolone in the treatment of brown spider bites. We used a purified venom that reproducibly produces a large eschar. To mimic real-life circumstances, all agents were administered following a 2-hour delay after envenomation. The animals were evaluated for the presence of coagulopathy to determine i...

INTRODUCTION Headaches represent over three million emergency department (ED) visits per year, comprising 2.4% of all ED visits. There are many proposed methods and clinical guidelines of treating acute headache presentations. However, data on intravenous acetaminophen usage in these settings are lacking. In this study, we sought to determine the efficacy of intravenous (IV) acetaminophen as an...

This study investigates the crystallization of the endogenous surfactant nonoxynol 100 in Eudragit NE30D-free films during storage and the influences of nonoxynol 100 on the dissolution of diphenhydramine hydrochloric acid (HCl) pellets coated with Eudragit NE30D before and after aging at ambient conditions. Polarizing light microscopy showed that when Eudragit NE30D-free films were stored at a...

Unsurprisingly, a recent comparison of important international guidelines found conflicting advice about antihistamines, reflecting the uncertainty in international clinical practice: a US guideline recommends the use of diphenhydramine as second line treatment in anaphylaxis; evidence for this recommendation is graded as "expert opinion/ extrapolated from higher order evidence. DRUG INFORMATIO...

GENERIC NAME PAGE Brompheniramine 454 Carbinoxamine 454 Cetirizine 453 Chlorpheniramine 454 Cimetidine 455 Clemastine 454 Cromolyn sodium 455 Cyclizine 455 Cyproheptadine 454 Desloratadine 453 Dimenhydrinate 455 GENERIC NAME PAGE Diphenhydramine 454 Famotidine 455 Fexofenadine 453 Hydroxyzine 454 Loratadine 453 Meclizine 455 Nedocromil 455 Promethazine 455 Pyrilamine 455 Ranitidine 455 Tripelen...