D espite advances in the understanding of the pathophysiology of atherosclerosis and an applaudable reduction in cardiovascular mortality over the past 30 years, coronary artery disease (CAD) remains an important cause of mortality and morbidity in the UK. While primary prevention of CAD is a priority for modern medicine, so too is the need for development of non-invasive techniques for imaging...

Myocardial perfusion imaging (MPI) is a highly sensitive and specific test for noninvasive detection of coronary artery disease. Therefore, in patients with negative MPI results, further noninvasive testing is usually not pursued. We report a series of patients with negative MPI results in whom 64-slice computed tomographic coronary angiography accurately predicted flow-limiting coronary lesion...

Introduction: We aimed to assess whether the vasodilator effect of oral dipyridamole on the left ventricular systolic function in patients with suspected CAD is different from that of intravenous (IV) dipyridamole using Tc-99m MIBI myocardial perfusion gated SPECT. Methods: Eighty-nine patients (17 male, 72 female; 61±10 years) were enrolled in this study. The patients underwent a dipyridamole ...

Coronary artery disease (CAD) is an important cause of morbidity and mortality worldwide. Perfusion abnormalities precede wall motion abnormalities, ECG changes, angina in the etiology CAD. myocardial perfusion imaging (MPI) can detect alterations due to pathology at sites such as endothelium, microvasculature, epicardial coronary arteries. Thus, it measures universal burden ischemic heart (IHD...

Background Quantitative analysis can improve myocardial perfusion imaging (MPI) for prediction of prognosis. We have designed a novel approach, Decisions Informed by Computed Entities (DICE), to enhance the prognostic ability of MPI data to predict major adverse cardiovascular events (MACE) in women with suspected ischemic heart disease. We applied DICE to cardiovascular magnetic resonance imag...

dextrocardia is a cardiac positional anomaly in which the heart is located in the right hemithorax with its base-to-apex axis directed to the right and caudad. situs inversus is an autosomal recessive disorder that causes organs in the chest and abdomen to be positioned in a mirror image from their normal position. dextrocardia may occur in isolation or as part of situs inversus. similarly, sit...

introduction: left ventricular ejection fraction (lvef) is considered to be the single most important prognostic factor in patients with previous myocardial infarction. lvef is not improved in all patients after coronary artery bypass grafting (cabg). this study aimed to assess the possibility of prediction of lvef changes after cabg using myocardial perfusion gated signle photon emission compu...

INTRODUCTION Pre-clinical investigation of stem cells for repairing damaged myocardium predominantly uses rodents, however large animals have cardiac circulation closely resembling the human heart. The aim of this study was to evaluate whether SPECT/CT myocardial perfusion imaging (MPI) could be used for assessing sheep myocardium following an acute myocardial infarction (MI) and response to in...

BACKGROUND The prognostic value of tomographic myocardial perfusion imaging with dipyridamole or adenosine in patients with left bundle-branch block has not been established. METHODS AND RESULTS The study group consisted of 245 patients with left bundle-branch block who underwent tomographic (single photon emission tomography) myocardial perfusion imaging with thallium-201 (n=173) or techneti...