Twenty-eight patients with previously untreated diffuse histiocytic lymphoma (DHL) were identified to be in pathologic stage (PS) I (11), IE (3), II (8), or IIE (6) by exploratory laparotomy and splenectomy. Six patients were treated with total nodal radiotherapy; 14 with an extended mantle; 5 with an inverted Y or whole abdomen; and 3 with an involved field. Twenty-six patients achieved a comp...

Background: Non Hodgkin’s lymphoma is an extremely chemo sensitive with a five year event free survival of greater than 90% in developed countries and a one year survival rate of 40-50% in developing countries. There have been no documented studies done at Kenyatta National Hospital on the various challenges faced by patients and their guardians that may hinder its optimal management.

OBJECTIVE The prevalence of breast cancer varies among countries and regions. This retrospective study investigated the prognostic value of the lymph node ratio (LNR) compared with the number of positive lymph nodes (pN) in Chinese breast cancer patients. METHODS The medical records of female breast cancer patients (N = 2591) were retrospectively evaluated. The association of LNR and TMN stag...

PURPOSE Elderly patients with rectal cancer are regarded as being at increased risk during radical resection because of lack of functional reserve and increased number of comorbidities. The aim of this study was to compare the short- and long-term outcomes of laparoscopic surgery with radical intent between elderly and young rectal cancer patients. METHODS Three-hundred ten patients who under...

Overall Survival Results of a Trial Assessing Patient-ReportedOutcomes for Symptom Monitoring During Routine Cancer Treatment Symptoms are common among patients receiving treatment for advanced cancers,1 yet are undetected by clinicians up to half the time.2 There is growing interest in integrating electronic patient-reported outcomes (PROs) into routine oncology practice for symptom monitoring...

Background/Aim: Previous studies of node-negative oral squamous cell carcinoma have shown a benefit elective neck dissection compared to observation. Evidence for radiotherapy as single-modality treatment the is so far lacking. Patients and Methods: In retrospective material 420 early-stage cancers from 2000 2016, overall survival, disease-free regional relapse-free survival were calculated wit...

background: the aim of this study was to investigate the efficacy and safety of metronomic capecitabine chemotherapy in pretreated elderly patients with advanced gastric carsonoma. patients and methods: eligible patients were treated with capecitabine at a fixed dose of 1000mg daily until disease progression or toxicity. endpoints were overall response rate, safety, progression-free survival an...

Rhabdomyosarcoma (RMS) is rare disease in adults (age >or= 16 years). The data from randomized prospective trials are scarce; the clinical outcome of these patients seems poor with the currently available treatment strategies. In this study, we report a single institution's experience in the treatment of adult RMS. We reviewed the medical records of patients with RMS who were >or= 16 years and ...

Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...