Distraction osteogenesis is an effective method for generating large amounts of bone in situ for treating pathologies such as large bone defects or skeletal malformations, for instance leg-length discrepancies. While an optimized distraction procedure might have the potential to reduce the rate of complications significantly, our knowledge of the underlying mechanobiological processes is still ...

In orthodontics, bone structure, its density and dimensions play an essential role by explaining limitations in magnitude, size and extent of tooth movement. Severe anterior crowding is one of the most frequently encountered dental malocclusions. Its therapy is mostly limited by lack of basal and alveolar bone and it often involves tooth extractions. Mandibular midline distraction osteogenesis ...

BACKGROUND The purpose of this study was to confirm the utility of a corrected cephalometric analysis to facilitate the planning of distraction osteogenesis with Le Fort III osteotomy for syndromic craniosynostosis. METHODS This prospective study involved 4 male and 2 female patients (mean patient age, 8 years 9 months; age range, 4 years 6 months to 13 years 2 months) with Crouzon syndrome w...

In a recent study, we observed that saccadic distraction (i.e., the remote distractor effect, RDE) was reduced when target and distractor were displayed at unequal contrast [Born, S., & Kerzel, D. (2008). Influence of target and distractor contrast on the remote distractor effect. Vision Research, 48(28), 2805-2816]. We hypothesized that arrival times explain the RDE modulation: With equal cont...

Around 1970, after overcoming obstacles related to anesthesia, infection, and blood supply, orthognathic surgeons come into their own. The history of cleft lip and palate treatment has a much earlier beginning because a deformed infant evokes a strong desire to intervene. Angle’s belief that orthodontists can grow bone finally came to fruition with the advent of distraction osteogenesis, which ...

Children with mandibular growth deficiency may develop airway obstruction. The standard treatment of severe airway obstruction involves invasive procedures such as tracheostomy. Mandibular distraction osteogenesis has been proposed in neonates with mandibular deficiency as a treatment option to avoid tracheostomy procedure later in life. Both tracheostomy and distraction osteogenesis procedures...

Distraction osteogenesis, currently a standard method of bone lengthening, is based upon the "tension-stress principle", as proposed by G.A. Ilizarov. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes including differentiation of pluripotential tissue, angiogenesis, mineralization, and remodeling. ...