UNLABELLED A proangiogenic role for Jagged (JAG)-dependent activation of NOTCH signaling in the endothelium has yet to be described. Using proteins that encoded different NOTCH1 EGF-like repeats, we identified unique regions of Delta-like ligand (DLL)-class and JAG-class ligand-receptor interactions, and developed NOTCH decoys that function as ligand-specific NOTCH inhibitors. N110-24 decoy blo...

Although clathrin assembly by adaptor proteins (APs) plays a major role in the recycling of synaptic vesicles, the molecular mechanism that allows APs to assemble clathrin is poorly understood. Here we demonstrate that AP180, like AP-2 and AP-3, binds to the N-terminal domain of clathrin. Sequence analysis reveals a motif, containing the sequence DLL, that exists in multiple copies in many clat...

Since its discovery, differential linear logic (DLL) inspired numerous domains. In denotational semantics, categorical models of DLL are now commune, and the simplest one is Rel, the category of sets and relations. In proof theory this naturally gave birth to differential proof nets that are full and complete for DLL. In turn, these tools can naturally be translated to their intuitionistic coun...

This case presentation explores how two key Drosophila morphogens, Decapentaplegic (Dpp) and Wingless (Wg), control the expression of two wing disc transcription factors, Vestigial (Vg) and Distalless (Dll). Two simple models for the potential control of Vg and Dll expression by Dpp and Wg in the mature steady state Drosophila wing pouch are explored. Firstly, a model based on the activation me...

In diesem Artikel geht es um die Implementierung der DLL-Einheiten im Hochschulsystem und ihre Ergebnisse. Darüber hinaus umfasst Hypothesen über den Einsatz DLL-Einheiten, Schwierigkeiten bei Anwendungsphase dazu Lösungsvorschläge. Es wurden Bestandteile vorteilhafte Ergebnisse Lernenden beschrieben. Die in Einheiten umfassenden Themen, für Lehrperson relevant sind, sind Beitrag Betracht gezog...

The endothelial cell-specific microRNA (miRNA), miR-126, is considered a master regulator of physiological angiogenesis. Transplanted mesenchymal stem cells (MSCs) release soluble factors contributing to neoangiogenesis and cardiac repair. Therefore, we hypothesized that the over-expression of miR-126 may prolong MSC survival and enhance the cell secretome, thereby improving post-infarction ang...

Developmental fields are subdivided into lineage-restricted cell populations, known as compartments. In the eye imaginal disc of Drosophila, dorso-ventral (DV) lineage restriction is the primary event, whereas antero-posterior compartment boundary is the first lineage restriction in other imaginal discs. The Iroquois complex (Iro-C) genes function as dorsal selectors and repress the default, ve...