To evaluate the suitability of dimethyl sulfoxide (DMSO) as a solvent for muscle-contraction studies in the chicken, its effect on the slow muscle contracture induced by high-K(+) solution was explored using the anterior latissimus dorsi (ALD) muscle from one-week-old chicks. Measurements were made of isometric tension and various characteristics of the contractures [peak tension, total tension...

-The effect of exogenous and endogenous prostaglandins on the patterns of growth and differentiation of Friend erythroleukaemia cells (FLC) were studied. During the differentiation process, DMSO stimulated PGE synthesis by an average of 95o%. The addition of a long-acting synthetic analogue of PGE2, 16,16-dimethylPGE2-methyl ester (di-M-PGE2) to the culture medium only slightly and temporarily ...

Five solutions of sodium chloride in mixtures of water and dimethyl sulphoxide ͑DMSO͒ have been simulated using the conventional molecular dynamics technique. The potentials of mean force ͑PMFs͒ of the sodium chloride ion pair in the presence of the five water–DMSO mixtures with DMSO mole fractions (x DMSO) of 0.10, 0.21, 0.35, 0.48 and 0.91 have been computed. The derived PMFs have been confirmed ...

The solvation of N-methylformamide (NMF) by dimethylsulfoxide (DMSO) in a 20% NMF/DMSO liquid mixture is investigated using a combination of neutron diffraction augmented with isotopic substitution and Monte Carlo simulations. The aim is to investigate the solute-solvent interactions and the structure of the solution. The results point to the formation of a hydrogen bond (H-bond) between the H ...

BACKGROUND Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed. METHODS AN...

Exposure of HepG2 cells to 1% (v/v) dimethyl sulfoxide (DMSO), an effective free radical scavenger, for 24 h resulted in a 2-fold increase in the levels of apolipoprotein (apo) A-I mRNA and secreted protein, with no significant change in apoA-II, apoB, and apoE mRNA and protein levels. The induction of apoA-I was accompanied by a 50% increase in secreted HDL. Nuclear run-off assays indicated th...

A series of M[Au(CN)(2)](2)(analyte)(x) coordination polymers (M = Co, Ni; analyte = dimethylsulfoxide (DMSO), N,N-dimethylformamide (DMF), pyridine; x = 2 or 4) was prepared and characterized. Addition of analyte vapours to solid M(μ-OH(2))[Au(CN)(2)](2) yielded visible vapochromic responses for M = Co but not M = Ni; the IR ν(CN) spectral region changed in every case. A single crystal structu...

background: cryopreservation of mammalian ovaries has been reported with different levels of success. cryopreservation of ovarian tissue may be a potential alternative for treatment of infertility and many attempts have been done to improve the efficiency of ovarian cryopreservation. the objective of the present study was to compare the direct cover vitrification (dcv) with ethylene glycol (eg)...

Our laboratory has shown that the efficacy of bladder cancer intravesical therapy is in part limited by the poor penetration of drugs into the urothelium. We further found that paclitaxel, because of its lipophilicity, shows a higher penetration than other commonly used drugs such as mitomycin C and doxorubicin. However, the commercial formulation of paclitaxel (i.e., Taxol) contains Cremophor,...