background: increase in world population is one of the serious and threatening issues in this century. therefore, it is vitally important to find safe and effective contraceptive methods, especially for men which already have few choices in this regard. medicinal plants that were used for contraception in ancient times could be good sources of investigation in this filed. ruta graveolens l. is ...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Human assisted reproduction results have improved dramatically in the last 20 years, with lower complications for the patient as well as for the newborns. This requires a precise clinical diagnosis that will allow us to individualize the best-personalized treatment for each patient or couple. But still today, the basi...

Male factors leading to infertility account for at least half of all cases of infertility worldwide. The purpose of this review is to highlight the importance of sperm DNA integrity. A systematic literature search was performed up to January 2015 in order to determine the impact of sperm DNA integrity and of the techniques used to determine it. Only articles presenting sperm aneuploidy together...

BACKGROUND We evaluated the impact of testicular germ cell cancer (TGCC), its treatment and length of follow-up on sperm DNA integrity. METHODS In 96 TGCC patients, semen was collected at specific intervals until 5 years after treatment. Sperm DNA integrity was assessed by the sperm chromatin structure assay (SCSA, n = 193) and by the terminal deoxynucleotidyl transferase-mediated dUTP nick-e...

OBJECTIVE To assess the effect of implementing different previtrification interventions on the postwarming DNA integrity of vitrified blastocysts. DESIGN Prospective in vitro study. SETTING Center for Reproductive Medicine laboratory in a tertiary hospital setting. ANIMALS A total of 70 expanded and 46 nonexpanded mouse blastocysts were used for the study. INTERVENTION(S) [1] Twenty-two...

Objective: To compare the effectiveness of carbon dioxide and carbon dioxide-free incubation system in extracting motile, morphologically normal and chromatin intact sperm populations from the individual semen samples. Materials and Methods: Semen samples were obtained from normozoospermic men presenting for infertility evaluation. Individual samples were divided into two equal aliquots for spe...

The traditional semen analysis is a cornerstone in diagnosis and treatment of male fertility (World Health Organisation (WHO), 1999, 2010). The sperm parameters concentration, motility and morphology are, however, claimed to be poor predictors of a male ́s fertility status, this in natural conception (Bonde et al., 1998; Guzick et al., 2001) as well as in assisted reproductive techniques (ART) (...

DNA methylation regulates many cellular processes, including embryonic development, transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and chromosome stability. DNA methyltransferases establish and maintain the presence of 5-methylcytosine (5mC), and ten-eleven translocation cytosine dioxygenases (TETs) oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosi...

DNA lesions and the repair mechanisms that maintain the integrity of genomic DNA are important in preventing carcinogenesis and its progression. Notably, mutations in DNA repair mechanisms are associated with cancer predisposition syndromes. Additionally, these mechanisms maintain the genomic integrity of cancer cells. The majority of therapies established to treat cancer are genotoxic agents t...

Medicinal plant possessed antifungal effects by many mechanisms, they caused membrane disturbance resulting in the loss of integrity, inhibited DNA transcription and reduced cell populations, activity fungal antioxidant enzymes biofilm formation. The current review discussed medicinal plants.