OBJECTIVE To evaluate the efficacy of domperidone in combination with omeprazole in the treatment of laryngopharyngeal reflux (LPR) compare to omeprazole alone. MATERIAL AND METHOD A prospective and randomized study included seventy patients with a reflux symptom index (RSI) 13 or more. They received either domperidone 10 mg thrice daily plus omeprazole 20 mg twice daily or omeprazole alone f...

OBJECTIVE This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013. MATERIALS AND METHODS The data collection was performed by the Short-Form Leeds Dyspepsia Q...

The aim of this study was to prepare fast disintegrating combination tablets of Omeprazole and Domperidone by using pertinent disintegrant. The tablets were prepared using mannitol as diluent and sodium saccharin as sweetening agent along with three different levels of disintegrant. The superdisintegrant used in this study were Kollidon CL, Ac-Di-Sol and SSG. The tablets were evaluated for weig...

OBJECTIVE While acetylcholinesterase inhibitors, such as donepezil, galantamine, and rivastig-mine, are beneficial in treating behavioral symptoms of patients with Alzheimer's disease (AD), their dose-limiting effects include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. We aimed to predict the occurrence of these gastrointestinal disturbances with rivastigmine therapy ...

UNLABELLED Gastrointestinal motor function in patients with primary anorexia nervosa has rarely been investigated. We studied oesophageal motor activity in 30 consecutive patients meeting standard diagnostic criteria for primary anorexia nervosa (Feighner et al; DSM III). Seven were found to suffer from achalasia instead of primary anorexia nervosa, one from diffuse oesophageal spasm and one fr...

OBJECTIVE To find out the effects of domperidone in combination with omeprazole in the treatment of chronic superficial gastritis (CSG). METHODS Ninety-six patients who suffered from CSG and received treatment in the Binzhou People's Hospital from July 2013 to July 2014 were selected as research subjects. They were divided into a control group (48 cases) and a test group (48 cases) using doub...

Microiontophoretic studies using rats anesthetized with chloral hydrate were performed to elucidate the relationship between the striatal cholinergic system and nigrostriatal dopaminergic system. Iontophoretic application of carbachol inhibited the spikes elicited by substantia nigra (SN) stimulation in 21 of 24 caudate neurons in which the spikes induced by SN stimulation were inhibited by mic...

The prodromal syndrome of radiation sickness is characterized by nausea and vomiting but the pathophysiology and the treatment of this entity is largely unknown. We investigated this problem by determining the effects of ionizing radiation on gastric function with and without administration of the dopamine antagonist domperidone. We measured gastric electrical control activity (waves per minute...

After the parenteral administration of bromocriptine (simulating ‘‘fescue toxicosis’’), oral domperidone was effective in resolving preand postpartum agalactia and prolonged gestation in pregnant pony mares. Oral reserpine was ineffective in treating prepartum agalactia and prolonged gestation; however, it did resolve postpartum agalactia. Unlike domperidone, reserpine induced sedation and diar...