Unipolar brush cells (UBCs) are glutamatergic interneurons in the cerebellar cortex and dorsal cochlear nucleus. We studied the development of UBCs, using transcription factor Tbr2/Eomes as a marker for UBCs and their progenitors in embryonic and postnatal mouse cerebellum. Tbr2+ UBCs appeared to migrate out of the upper rhombic lip via two cellular streams: a dorsal pathway into developing cer...

The localization of glycine (GR) and adrenergic receptors (AdR) was examined in the rat brain using a monoclonal antibody against the affinity purified glycine receptor and a polyclonal antibody against purified beta2-AdR. GR were concentrated in the lower brainstem, whereas no immunoreactivity was observed in the diencephalon and forebrain except in a few diencephalic nuclei. The highest densi...

In the cochlear nucleus, there is a magnocellular core of neurons whose axons form the ascending auditory pathways. Surrounding this core is a thin shell of microneurons called the granule cell domain (GCD). The GCD receives auditory and nonauditory inputs and projects in turn to the dorsal cochlear nucleus, thus appearing to serve as a central locus for integrating polysensory information and ...

Many studies have explored how neuromodulators affect synaptic function, yet little is known about how they modify computations at the microcircuit level. In the dorsal cochlear nucleus (DCN), a region that integrates auditory and multisensory inputs from two distinct pathways, serotonin (5-HT) enhances excitability of principal cells, predicting a generalized reduction in sensory thresholds. S...

Evidence has accumulated linking clinical tinnitus to the somatosensory system. Most clinical tinnitus patients can change the psychoacoustic attributes of their tinnitus with forceful head and neck contractions. The significance of such somatic modulation of tinnitus was assessed by testing non-clinical subjects. Like clinical tinnitus patients, about 80% of non-clinical subjects who had ongoi...

Neurons in the ventral cochlear nucleus (VCN) that respond primarily at the onset of a pure tone stimulus show diversity in terms of peri-stimulus-time-histograms (PSTHs), rate-level functions, frequency tuning, and also their responses to broad band noise. A number of different mechanisms have been proposed as contributing to the onset characteristic: e.g. coincidence, depolarisation block, an...

Multiple classes of inhibitory interneurons shape the activity of principal neurons of the dorsal cochlear nucleus (DCN), a primary target of auditory nerve fibers in the mammalian brain stem. Feedforward inhibition mediated by glycinergic vertical cells (also termed tuberculoventral or corn cells) is thought to contribute importantly to the sound-evoked response properties of principal neurons...

Coffee and light refreshments will be provided at the session breaks. Posters should remain in place for all of Monday and Tuesday. Discussion time is scheduled during the meeting. In addition, a limited amount of space for the presentation of posters is possible on Wednesday. The size of poster boardse is 1.5m wide x 1m high. The poster display areas will be in the atrium and meeting rooms nea...

A hallmark of brain organization is the integration of primary and modulatory pathways by principal neurons. However, the pathway interactions that shape primary input processing remain unknown. We investigated this problem in mouse dorsal cochlear nucleus (DCN) where principal cells integrate primary, auditory nerve input with modulatory, parallel fiber input. Using a combined experimental and...

2 3 4 5 6 7 Nonlinear temporal receptive fields of neurons in the dorsal cochlear nucleus 8 9 10 Sharba Bandyopadhyay, and Eric D. Young 11 12 National Brain Research Centre, Manesar, HR 122051, India 13 14 Center for Hearing and Balance, Johns Hopkins Univ., Baltimore, MD 21205 USA 15 16 17 18 19 20 21 22 Running head: DCN temporal envelope processing 23 24 25 Correspondence: 26 Eric D. Young ...