Valdecoxib, a selective COX-2 inhibitor, produces serious side effects when given orally. This has led to its withdrawal. Topical application of valdecoxib was formulated and evaluated for its efficacy and safety. Standard procedures were followed and male Wistar albino rats were used to test the anti-inflammatory effect and effect in hyperalgesic conditions. Ointments, creams, and gels contain...

§ 522.313a Ceftiofur crystalline free acid. * * * * * (e) * * * (2) * * * (i) Amount. For subcutaneous (SC) injection in the posterior aspect of the ear where it attaches to the head (base of the ear) in lactating dairy cattle. For SC injection in the middle third of the posterior aspect of the ear or in the base of the ear in beef and non-lactating dairy cattle. (A) Single-dose regimen: 6.6 mg...

Formulators are charged with the responsibility to formulate a bioequivalent product (in case of ANDA) product which is physically and chemically stable, manufacturable at commercial scale. Different crystal structures in polymorphs arise when the drug substance crystallizes in different crystal packing arrangements and/or different conformations. Besides, Polymorphs cocrystallization is now im...

A Simple fast and precise reversed phase high performance liquid chromatographic method is developed for the Deflazacort drug. Chromatographic separation was performed a C18 column (250×4.6 mm) as a stationary phase with the mobile phase of Acetonitrile, methanol and water (90:5:5 v/v). Flow rate is 1.0 ml/min the detection of wave length is 230 nm. This method was validated for linearity, accu...

PURPOSE To prepare a suspension form of diclofenac and compare the influence of the injected form (suspension versus solution) on the intravitreal pharmacokinetics of diclofenac in Dutch belted pigmented rabbits. METHODS Diclofenac acid was prepared and characterized in a suspension formulation. Rabbit eyes were injected with either diclofenac sodium solution (0.3 mg) or diclofenac acid suspe...

New, simple, accurate, sensitive, economical, and reproducible UV-spectrophotometric method was developed and validated for the estimation of Lacidipine in bulk and tablet dosage form. Lacidipine shows maximum absorbance at 615.7 nm and linearity (Beer’s Lamberts law) was found to be in the range of 10-70 μg/ml. The apparent molar absorptivity and Sandell’s sensitivity coefficient were found to...