The Effect of Sertreline Versus Nortriptyline on Quality Life and Depression After Stroke:A Randomized Double-Blind Controlled Study

R. Gupta, U. Sharma, N. Gupta, U. Singh, R. Guleria, N. R. Jagannathan, and R. Goswami Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, Delhi, India, Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, 5Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, Delhi, Ind...

Seventy-five dogs that showed a fear response to fireworks participated in a double-blinded, placebo-controlled clinical trial to assess the efficacy of a homeopathic remedy for the alleviation of their behavioural signs. Dogs were randomly assigned to one of two treatments; the homeopathic treatment or the placebo treatment. At the baseline assessments the owners identified the behavioural sig...

Study selection Studies were selected if they were unconfounded, double blind, randomised controlled trials that compared selegiline with placebo in patients with Alzheimer’s disease. Studies had to have been reported before the end of 1998; patients had to meet NINCDSADRDA or DSM criteria for Alzheimer’s disease; and any secondary treatments (eg, physostigmine and lecithin) had to be given to ...

BACKGROUND Propofol and fentanyl are the most widely administered anesthesia maintaining drugs during colonoscopy. In this study, we determined the median effective concentration (EC50) of propofol required for colonoscopy in elderly patients, and the purpose of this study was to describe the pharmacodynamic interaction between fentanyl and propofol when used in combination for colonoscopy in e...

First-time-in-human studies are small, time-lagged dose-escalation studies including volunteer subjects evaluating safety and tolerability. There is little consensus in the design of a first-time-in-human study, and it is difficult to get an overview of studies performed. One hundred five studies comprising 3323 healthy volunteers published in the 5 major clinical pharmacology journals since 19...

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OBJECTIVE To compare efficacy and safety of 50 μgm misoprostol vaginal with oral for labor induction. METHODS 110 women at term gestation, Bishop score ≤4, with various indications for labor induction were randomized and double blinded. After decoding 51 women had received misoprostol orally and 52 vaginally, four hourly (maximum six doses) or till woman went into active labor. RESULTS Stat...

OBJECTIVE To study the effect of nimesulide (4-nitro-2-phenoxymethane sulfonanilide) a non-steroidal anti-inflammatory drug, on antihistaminic activity of cetirizine. METHOD A randomized, double blind, cross over study was conducted in ten healthy male volunteers. Wheal and flare responses to histamine were measured by performing intradermal injection of histamine (2 micrograms base) diluted ...

Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine...