background: the negative symptoms of schizophrenia remain a major clinical challenge. nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. the aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia.   methods: this study is a six-week randomized placebo-control trial of nortriptyline or placebo...

We conducted a prospective, double-blind clinical trial to evaluate the differences in operating time, intraoperative blood loss, postoperative pain at 3 hours and 1 week, and delayed (>24 hr) bleeding associated with ultrasonic harmonic scalpel tonsillectomy and conventional tonsillectomy. The study was carried out on 28 patients with recurrent tonsillitis and/or adenotonsillar hypertrophy who...

Background: Intracerebral Hemorrhage (ICH) is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH. Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH. Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patient...

We present the results of a double-blind trial comparing the efficacy of betamethasone phosphate 0.1%, clobetasone butyrate 0.1%, and placebo in the treatment of acute unilateral nongranulomatous uveitis. The 2 steroids were equally comparable in improvement of the patients' symptoms, though betamethasone phosphate was significantly more effective than clobetasone butyrate in improving the ocul...

Objective: The use of single-case designs in intervention research is discussed. Regression methods for analyzing data from these designs are considered, and an innovative use of logistic regression to analyze data from a double-blind, randomized clinical trial of propranolol for agitation among persons with traumatic brain injury (TBI) is used. Method: Double-blind, randomized clinical trial p...

one of the most common complications of operation and anesthesia is shivering. the purpose of this study was to compare the effectiveness of ondanseton and meperedine in preventing shivering after off-pump coronary artery bypass graft (opcab). in this double-blind randomized clinical trial, the sample consisted of 90 patients, who were candidates of cabg under general anesthesia. these patients...

In a double-blind prospective trial clofibrate was found not to influence significantly the clinical and laboratory indices thought to reflect the state of fat embolism in patients with fractures.

Sixty patients were treated with either acyclovir 2% ointment or idoxuridine 1% ointment 5 times a day in a stratified randomised double-blind clinical trial. The 2 antiviral agents were equally effective.

background: we sought to evaluate the efficacy and safety of the different trade forms of streptokinase available in our country, namely heberkinasa (heberbiotec, havana, cuba) and streptase (aventis behring gmbh, marburg, germany). methods: we conducted a double-blind randomized clinical trial to compare the two streptokinase formulations, i.e. heberkinasa (hbk) or streptase (stp), in patients...