BACKGROUND Preoperative radiotherapy in resectable rectal cancer has a number of potential advantages, most importantly reducing local recurrence, increasing survival and down-staging effect. PURPOSE This prospective study was designed to compare between two different approaches of preoperative radiotherapy, either short course or long course radiotherapy. The primary endpoint is to evaluate ...

BACKGROUND To determine complete resection and sphincter preservation rates, down-staging, local control and survival associated with concurrent chemoradiotherapy (CCRT) using a moderately high pelvic radiation dose before surgery in rectal cancer. METHODS Fifty-seven patients with histologically proven adenocarcinoma of the mid to lower rectum were treated using preoperative CCRT and surgery...

AIM To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy. METHODS Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005 and 2011 at a single institution were reviewed. Triplet ...

cancer of the stomach carries poor prognosis. surgery is the best treatment for gastric cancer. prediction of survival depends on the stage at the time of presentation. fluoroscopy, sonography, and computerized tomography are used for advanced gastric cancers staging, but they are not accurate enough to grade advanced gastric cancers. laparoscopic findings of lesions under direct vision, are ma...

background beta catenin plays a key role in cancer tumorigenesis. however, its prognostic significance in patients with colorectal cancer (crc) remains controversial. it has been demonstrated that 90% of all tumors have a mutation in individual components of multiple oncogenes in wnt/β-catenin pathway. accumulation of nuclear β-catenin in cytoplasm leads to uncontrolled cell proliferation. thus...

Introduction: Multiple myeloma is a heterogeneous disease with different survival times among patients. Accurate prediction of prognosis in multiple myeloma is essential, as patients with a shorter survival time may require early bone marrow transplantation (BMT) and more advanced chemotherapy as a part of their first-line treatment. In the present study, a parameter, depicted by ga...