Self-interactions Proteins (SIPs) is important for their biological activity owing to the inherent interaction amongst their secondary structures or domains. However, due to the limitations of experimental Self-interactions detection, one major challenge in the study of prediction SIPs is how to exploit computational approaches for SIPs detection based on evolutionary information contained prot...

A matrix A is said to be strictly totally positive (STP) if all its minors are strictly positive. STP matrices were independently introduced by Schoenberg in 1930 (see [13, 14]) and by Krein and Gantmacher in the 1930s. The main results concerning eigenvalues and eigenvectors of STP matrices were proved by Gantmacher and Krein in their 1937 paper [6]. (An announcement appeared in 1935 in [5]. C...

On explicite l’approche de Cohn (1955) de la théorie de Markoff. On montre en particulier comment l’arbre complet des solutions de l’équation diophantienne associée apparaît comme quotient du groupe GL(2,Z) des matrices 2× 2 à coefficients entiers et de déterminant ±1 par un sous-groupe diédral D6 à 12 éléments. Différents développements intermédiaires sont faits autour du groupe Aut(F2) des au...

In December 2006 the BBC in London ran a major news article reporting the prediction by the research organisation, Cancer Research UK (CRUK) that soaring obesity levels would inevitably lead to a significant increase in ‘‘weight related’’ cancers [1]. The prediction was that there would be a 14% increase in obesity by 2010 and that this would cause an increase of 1500 extra cancers per year in ...

In the development of the Drosophila embryo, gene expression is directed by the sequence-specific interactions of a large network of protein transcription factors (TFs) and DNA cis-regulatory binding sites. Once the identity of the typically 8-10bp binding sites for any given TF has been determined by one of several experimental procedures, the sequences can be represented in a position weight ...

Fast search algorithms for finding good instances of patterns given as position specific scoring matrices are developed, and some empirical results on their performance on DNA sequences are reported. The algorithms basically generalize the Aho–Corasick, filtration, and superalphabet techniques of string matching to the scoring matrix search. As compared to the naive search, our algorithms can b...

The aim of the work described in this paper is to develop methods for automatically assessing the pronunciation quality of specific phone segments uttered by students learning a foreign language. From the phonetic time alignments generated by SRI's Decipher™ HMM-based speech recognition system, we use various probabilistic models to produce pronunciation scores for the phone utterance. We evalu...

A two-stage neural network has been used to predict protein secondary structure based on the position specific scoring matrices generated by PSI-BLAST. Despite the simplicity and convenience of the approach used, the results are found to be superior to those produced by other methods, including the popular PHD method according to our own benchmarking results and the results from the recent Crit...

Purpose The purpose of this paper is to propose and test a multi-criteria decision analysis (MCDA) approach based on an additive value function (AVF) select the most economically advantageous tender under European Union public procurement regulations. Design/methodology/approach A case study in which AVF evaluation model constructed by personnel results original, real-life are compared those di...