Solid lipid nanoparticles (SLNs) are an alternative carrier system used to load the drug for targeting, to improve the bioavailability by increasing its solubility, and protecting the drug from presystemic metabolism. The avoidance of presystemic metabolism is due to the nano-metric size range, so that the liver cannot uptake the drug from the delivery system and is not metabolized by the liver...

Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based such as insufficient targeting, capture by reticuloendothelial system, fast elimination limit efficiency therapeutic efficacy. Therefore, a series multifunction...

The aim of this work was to identify from a review current literature the effects lipids used in development Nanostructured Lipid Carriers (NLCs) on physicochemical properties resulting formulation. size solid lipid, affected by molecular weight and complexity structure, tends affect particle final formulation proportionally; higher more complex bigger NLCs. However, there is no straight correl...

This research work deals with the design and development of solid lipid nanoparticles Losartan to improve solubility poorly soluble drug. are formed using hot homogenization technique followed by ultrasonication technique. Experiment trend is predicted standard calibration curve. The parameters studied percent drug release, entrapment efficiency, particle size SLN in-vitro release prepared SLN....

Mimicking nature is a powerful approach for developing novel lipid-based devices for drug and vaccine delivery. In this review, biomimetic assemblies based on natural or synthetic lipids by themselves or associated to silica, latex or drug particles will be discussed. In water, self-assembly of lipid molecules into supramolecular structures is fairly well understood. However, their self-assembl...

Quantifying drug permeability across lipid membranes is crucial for drug development. In addition, reduced membrane permeability is a leading cause of antibiotic resistance in bacteria, and hence there is a need for new technologies that can quantify antibiotic transport across biological membranes. We recently developed an optofluidic assay that directly determines the permeability coefficient...

Currently, more than 90% of compounds identified are water insoluble and or poorly water soluble, which is a bottle neck in the development of many new drug candidates. These poorly soluble drug molecules are difficult to formulate using conventional approaches and are associated with numerous formulation‐related performance issues. Formulating these compounds using lipid‐based systems is one o...

Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are established that drive the offending drug from target tissues into the newly formed 'lipid sink'. Based on this hypothesis, lipid emulsion has been con...

Objective: To determine the prevalence and correlates of lipid lowering drug use among older British men with established coronary heart disease (CHD). Design: Cross sectional survey within a cohort study (British regional heart study) carried out at 20 years of follow up in 1998–2000. Setting: General practices in 24 British towns. Participants: 3689 men aged 60–75 years (response rate 76%). M...