Our previous studies on selenite cytotoxicity led us to hypothesize that drug resistant tumor cells with high intracellular glutathione »ill exhibit a high degree of sensitivity to selenite. To examine this we studied the effects of selenite on drug resistant human ovarian tumor (NIH:OVCAR-3) cells in three assays of cytotoxicity: proliferation; cell viability (in pan blue exclusion); and atta...

Our previous studies on selenite cytotoxicity led us to hypothesize that drug resistant tumor cells with high intracellular glutathione will exhibit a high degree of sensitivity to selenite. To examine this we studied the effects of selenite on drug resistant human ovarian tumor (NIH:OVCAR-3) cells in three assays of cytotoxicity: proliferation; cell viability (trypan blue exclusion); and attac...

Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PDX). Mimicking clinical behavior, triple-negative breast tumors (TNBCs) from PDX models were more sensitive to docetaxel than luminal tumors, but th...

Treatment approaches for advanced ovarian cancer should consider several factors. Among the most important are platinum sensitivity, status of BRCA and homologous recombination deficiency (HRD), changing indications PARP inhibitors in recurrent disease maintenance. have demonstrated clear benefit patients with mutated tumors, especially first-line setting, HRD testing can guide their use withou...

background there is limited data on outcomes of adolescents with drug-resistant tuberculosis (dr-tb). objectives to describe patient outcomes and factors associated with outcomes of adolescents diagnosed with dr-tb in khayelitsha, south africa. patients and methods a retrospective analysis of data for adolescents aged 10-19 years who were diagnosed with dr-tb between january 2008 and august 201...

silicosis is considered to be among the occupational lung diseases and associated with sandblasting, mining, quarrying and tunneling. acute silicosis is usually progressive diseaseand despite treatment with corticosteroids it leads to cardio-respiratory failure and death. alveolar silicoproteinosis is one of it’s acute presentations due to exposure to silica dust and lungs filling with proteina...

background methicillin-resistant staphylococcus aureus (mrsa) remains a significant public health problem and treatment challenge. objectives this study was conducted to determine the frequency, molecular types, and drug resistance of s. aureus isolated from nasal carriers in two teaching hospitals (hajar and kashani) in shahrekord, southwestern iran. methods in this cross-sectional study, 262 ...

BACKGROUND AND PROCEDURE MRP1 expression by neuroblastomas was evaluated by Northern blot analysis in 21 cell lines and 90 primary untreated tumors. Cytotoxicity assay in cell lines was performed for five anticancer drugs used in treating neuroblastoma. RESULTS MRP1 expression did not correlate with drug resistance or with MYCN RNA expression in cell lines. MRP1 expression was higher in drug-...

EMT-6 murine mammary tumor sublines highly resistant to cyclophosphamide, cis-diamminedichloro-platinum(II), or N,N',N"-triethylenethiophosphoramide were generated in vivo by sequential treatment of tumor-bearing mice with the respective drugs. Previous studies demonstrated the drug-resistant phenotypes of the sublines were not expressed in vitro when the cells were grown as monolayer cultures....

patients and methods two-hundred and fifty-five clinical specimens were collected from four major provinces of iran. samples were cultured and the mrsa strains were subjected to polymerase chain reaction (pcr). the patterns of antibiotic resistance were determined using the disk diffusion method. results seventy-four out of 255 (29.01%) clinical samples were positive for mrsa. of the 74 mrsa st...