 The physicochemical properties of the drug substance can assume a primary role in controlling its dissolution from the dosage form.  The aqueous solubility of the drug is one of the major factors that determine its dissolution rate.  Some studies concluded that the drug solubility data can be used as rough predictor of the possibility of any future problems with bioavailability.  Some of t...

The design of the present investigation was to prepare furosemide bounded pharmacosomes to enhance solubility and permeability drug by simple reproducible solvent evaporation technique and further investigated. Furosemide bounded pharmacosomes formulation (PMC1 & PMC2) was taken and compared with pure drug by way of enhanced solubility 5.4 fold in the water, 3.33, 4.76 fold in pH 7.4 and pH 5.8...

The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a f...

Introduction Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility ...

Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility to enhance dr...

Pioglitazone, a class II Biopharmaceutical Classification System drug having poor water solubility and slow dissolution rate may have a negative impact on its subtherapeutic plasma drug levels leading to therapeutic failure. In order to improve its water solubility and thus dissolution, cyclodextrin complexation technique was followed. The phase solubility studies were carried using three diffe...

The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactory general model is not yet available. The most cited challenge to good prediction has been the lack of enough highquality and drug-relevant solubility data that adequately cover the chemical space of drugs. This review addresses data quality in solubility measurement. Specifically, the “gold stan...

One of the important methods to improve the solubility of a less water-soluble drug is by the use of co solvents. The solubility enhancement produced by two binary blends with a common co solvent (water-propylene glycol and propylene glycol-ethyl acetate) was studied against the solubility parameter of solvent blends (δ(1)) to evaluate the solubility parameter of drug (δ(2)). The binary blend w...

The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal dru...