The application of appropriate rules for drug-drug interactions (DDIs) could substantially reduce the number of adverse drug events. However, current implementations of such rules in tertiary hospitals are problematic as physicians are receiving too many alerts, causing high override rates and alert fatigue. We investigated the potential impact of Korean national DDI rules in a drug utilization...

Alex Voorhoeve sets the stage for his book by quoting Plato's Phaedrus in which the “the living, breathing discourse of the man who knows” (1) is deemed superior to the written discourse. Socrates's vindication of the dialogue as the blessed form of philosophical investigation is thus presented as the inspiration for these eleven conversations with prominent thinkers on ethics ― most of them pr...

BACKGROUND It is possible that cross-over studies included in current systematic reviews are being inadequately assessed, because the current risk of bias tools do not consider possible biases specific to cross-over design. We performed this study to evaluate whether this was being done in cross-over studies included in Cochrane Systematic Reviews (CSRs). METHODS We searched the Cochrane Libr...

OBJECTIVE During peer review, submitted manuscripts are scrutinised by independent experts to assist journal editors in their decision-making and to help improve the quality of articles. In this retrospective cohort study, peer review comments for drug trials submitted to medical journals were analysed to investigate whether there is a relation between the content of these comments and sponsors...

The purpose of this systematic review and meta-analysis was to compare the efficacy of computer-assisted learning (CAL) with traditional methods of learning in orthodontic education. Comprehensive electronic and manual searches of randomized controlled trials and prospective studies were conducted. Participants considered were undergraduate or postgraduate orthodontic students or orthodontic ed...

BACKGROUND This review examines evidence for an association between computer work and carpal tunnel syndrome (CTS). METHODS A systematic review of studies of computer work and CTS was performed. Supplementary, longitudinal studies of low force, repetitive work and CTS, and studies of possible pathophysiological mechanisms were evaluated. RESULTS Eight epidemiological studies of the associat...

Laptop computer induced erythema ab igne is increasing in the last years. One of the important questions in evaluation erythema ab igne a patient is about the history of prolongs laptop exposure. We recommend awareness programs development in the future to laptop users about this condition and advise them to avoid placing laptops on their body for prolonged periods of time and direct them to pl...

Peer review is the "gold standard" for evaluating journal and conference papers, research proposals, on-going projects and university departments. However, it is widely believed that current systems are expensive, conservative and prone to various forms of bias. One form of bias identified in the literature is “social bias” linked to the personal attributes of authors and reviewers. To quantify...

OBJECTIVE To investigate whether for patients with incurable cancer comprehensive home care programmes are more effective than standard care in maintaining the patients' quality of life and reducing their "readmission time" (percentage of days spent in hospital from start of care till death). DESIGN Systematic review. METHODS A computer aided search was conducted using the databases of Medl...

rational prescribing increases the quality of health care and patient outcomes. in this study, the quality of drug prescription in specialist physicians in isfahan province of iran was assessed for evaluating the rational use of drugs and improving the therapeutic outcomes.this retrospective survey was conducted on a total of 7999530 prescriptions from all general and specialist physicians. the...