GITR/TNFRSF18 is a member of the TNF-receptor superfamily preferentially expressed on regulatory T cells (Tregs) and activated T effector cells. Antibody agonists to GITR claim two distinct mechanisms to overcome the repressive tumor microenvironment and drive anti-tumor efficacy in vivo: receptor agonism (forward signaling) on T effector cells and FcgR-mediated Treg depletion. We sought to bet...

OBJECTIVES Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than in the general population and can complicate asthma management. The aim of this study was to evaluate the presence of OSA in patients with difficult-to-treat asthma (DTA) and to investigate the sleep quality in these patients. METHODS Patients with DTA were recruited from the adult allergy clinic of a tertia...

Background—Obesity and diabetes mellitus are complex metabolic problems of pandemic proportion, contributing to significant cardiovascular mortality. Recent studies have shown altered mitochondrial function in the hearts of diabetic animals. We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage. Methods...

Traffic congestion is a major problem in urban areas that has a significant adverse economic impact through deterioration of mobility, safety and air quality. As a result, the importance of better management of the road network to efficiently utilize existing capacity is increasing. To that end, many urban areas build and operate modern Traffic Management Centers (TMCs), which perform several f...

Advances in Intelligent Transportation Systems (ITS) have resulted in the deployment of surveillance systems that automatically collect and store extensive network-wide traffic data. Dynamic Traffic Assignment (DTA) models have also been developed for a variety of dynamic traffic management applications. Such models are designed to estimate and predict the evolution of congestion through detail...

The aim of this paper is to report a salvage treatment for malpositioned stent graft due to mislabeled product during thoracic endovascular aortic repair (TEVAR) in descending thoracic aneurysm (DTA). A 78-year-old male presented with 6.7×4.1 cm sized saccular DTA and 7.1×7.3 cm sized abdominal aortic aneurysm (AAA). DTA was initially treated by TEVAR and 2 months later AAA was treated by open ...

Curative surgery is possible in barely 10% of patients with colorectal liver metastases and combined treatment modalities scarcely improve survival in this group of patients. Hence, investigations of new therapeutic modalities are crucial. Overexpression of the H19 gene in liver metastases points to H19 as a target for cancer gene therapy. Here we have evaluated the possibility of regional intr...

The thermogravimetric analysis (TGA) and the differential thermal analysis (DTA) were applied to investigations of aging processes in some electroinsulating polymeric materials (glass reinforced epoxy resin, NBR ( two sorts), styrenated unsatured polyester resin, hydrogenated NBR (T80), polychloroprene rubber , EPR) and to the measurement of aging reaction rates. It is shown that thermal analys...

Expert assessments for crop and range productivity of very-large arid and semiarid areas worldwide are ever more in demand and these studies require greater sensitivity in delineating the different grades or levels of soil salinity. In conjunction with field study in arid southeastern Oregon, we assess the merit of adding decision-tree analysis (DTA) to a commonly used remote-sensing method. Ra...