Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes are implicated in the pathogenesis of these infections; however, their specific roles are not well defined. To investigate the role of inflammatory Ly6ChiCCR2+ monocytes in alphavirus pathogenesis, we used CCR2-DTR transgenic mic...

BACKGROUND Early and accurate identification of factors that predict post-stroke cognitive outcome is important to set realistic targets for rehabilitation and to guide patients and their families accordingly. However, behavioral measures of cognition are difficult to obtain in the acute phase of recovery due to clinical factors (e.g. fatigue) and functional barriers (e.g. language deficits). T...

This paper summarises an updated climate change trends analysis—developed for the period from 1 October 1864 to 30 September 2021 within scope of a Horizon 2020-funded project increase resilience in European coastal cities—for representative site Lisbon Metropolitan Area (Portugal). By using long ground-based daily records rainfall and surface temperature at Lisboa-Geofísico climatological stat...

The rise in the frequency and magnitude of extreme temperature phenomena across globe has led to recurrent incidence global climate hazards, which have had severe effects on socioeconomic development. daily maximum minimum datasets 27 sites Bangladesh were used detect spatiotemporal trends extremes over during 1980–2017 based ten indices using multi-statistical modeling namely linear regression...

Ab-secreting cell (ASC) expansion and survival are important processes in optimizing vaccines and controlling autoimmunity. The microenvironment of the medullary cords is positioned to control these key processes. Previously, we imaged and characterized ASC differentiation and migration by intravital microscopy in the lymph node (LN) by transferring and activating B cells expressing yellow fluo...

Although monocytes/macrophages are considered important in atherogenesis, their role in established plaques is unclear. For example, macrophage content is associated with plaque instability, but their loss through cell death is observed at sites of plaque rupture. To examine the role of monocytes/macrophages in atherosclerosis, we developed CD11b-diphtheria toxin (DT) receptor (DTR) transgenic ...

INTRODUCTION Acute kidney injury (AKI) is a major risk factor in the development of chronic kidney disease (CKD). However, the mechanisms linking AKI to CKD remain unclear. We examined the alteration of macrophage phenotypes during an extended recovery period following ischemia/reperfusion injury (IRI) and determine their roles in the development of fibrosis. METHODS The left renal pedicle of...

Hybrid wireless networks combining the advantages of both mobile ad-hoc networks and infrastructure wireless networks have been receiving increased attention due to their ultra-high performance. An efficient data routing protocol is important in such networks for high network capacity and scalability. However, most routing protocols for these networks simply combine the ad-hoc transmission mode...

Most non-trivial data processing scenarios using Hadoop typically involve launching more than one MapReduce job. Usually, such processing is data-driven with the data funneled through a sequence of jobs. The processing model could be expressed in terms of dataflow programming, represented as a directed graph with datasets as vertices. Using fuzzy timestamps as a way to detect which dataset need...

On a foliated Riemannian manifold (M, gM ,F) with a transverse spin foliation F , we estimate a lower bound for the square of the eigenvalues of the transversal Dirac operator Dtr.