In late mitosis and G1, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2-7. A "licensing checkpoint" delays cells in G1 until sufficient origins have been licensed, but this checkpoint is lost in cancer cells. Inhibition of licensing can therefore kill cancer cells while only delay...

Transactions provide a language construct that programmers can use to specify that operations execute atomically, in isolation from all computation outside the transaction. Transactions permit optimistic concurrency for accesses to shared data, which may improve performance over locking mechanisms. Transactions also allow programmers to specify atomic regions in a composable way, which locks do...

As carbon dioxide emissions arising from fossil energy consumption and fuels are gradually increased, it is important for the low-carbon operation of ships to recover diesel engine waste heat. A newly developed dual-loop organic Rankine cycle (ORC) system heat a marine main (M/E) was designed in this paper. The exhaust gas (EG) recovered by high-temperature (HT) loop. jacket cooling water (JCW)...

Due to energy shortage and global warming, issues of energy saving have become more important. To increase the energy efficiency and reduce the fuel consumption, waste heat recovery is a significant method for energy saving. The organic Rankine cycle (ORC) has great potential to recover the waste heat from the core jet exhaust of a turbofan engine and use it to produce power. Preliminary study ...

OBJECTIVE Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds. DESIGN A multidisciplinary panel mee...

PURPOSE The aim of this study was to assess the advantages of robotic surgery, comparing perioperative and oncological outcomes between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC). MATERIALS AND METHODS Between August 2008 and May 2014, 112 radical cystectomies (42 RARCs and 70 ORCs) were performed at a single academic institution following Institutional Review ...

Using zeotropic mixtures as working fluids can improve the thermal efficiency of Organic Rankine cycle (ORC) power plants for utilising geothermal energy. However, currently, such ORC systems cannot regulate the composition of zeotropic mixtures when their operating conditions change. A compositionadjustable ORC system could potentially improve the thermal efficiency by closely matching the cyc...

The origin recognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing, sister chromatid cohesion, telomere biology, heterochromatin localization, centromere and centrosome activity, and cytokinesis. We show that, in human cells, multiple ORC subunits associate with hetereochromatin protein 1 (HP1) alpha- and ...

BACKGROUND Radical cystectomy is the gold-standard management for muscle-invasive bladder cancer, and there is debate concerning the comparative effectiveness of robotic-assisted (RARC) versus open radical cystectomy (ORC). OBJECTIVE To compare utilization, perioperative, cost, and survival outcomes of RARC versus ORC. DESIGN, SETTING, AND PARTICIPANTS We identified bladder urothelial carci...

The most effective and environmentally safe fossil fuel power production facilities are the combined cycle gas turbine (CCGT) ones. Electric efficiency of advanced is up to 58% in Russia 64% abroad. further improvement thermal by increase inlet temperature (TIT) limited performance heat resistance alloys that used for hot path components cooling system efficiency. An alternative method CCGT uti...