abstract   background: the polymorphic variants at codon 72 of the p53 gene, encoding either proline or arginine at residue 72, produce marked change in the structure of p53. from the evidence that the dnamismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that the codon 72 variation may influence the prevalence of microsatellite instability a feature of malig...

ÐFreezing lesions to the developing cortical plate of rodents results in a focal malformation resembling human 4layered microgyria, and this malformation has been shown to result in local and widespread disruptions of neuronal architecture, connectivity, and physiology. Because we had previously demonstrated that microgyria caused disruptions in callosal connections, we hypothesized that freeze...

we report an unusual case of hemimegalencephaly (hmg) associated with ipsilateral congenital-infiltrating lipomatosis of the face in a five-month-old boy. hemimegalencephaly is a rare but unique malformation characterized by enlargement of all or parts of a cerebral hemisphere. the affected hemisphere may have focal or diffuse neuronal migration defects, with areas of polymicrogyria, pachygyria...

sialography is the retrograde injection of an iodinated contrast agent into the ductal system of salivary glands and this technique is the only method capable of adequately demonstrating the status of the ductal system. one of the indications of sialography is classification of the salivary ductal system fistulae. this classification has important prognostic and therapeutic values. in the prese...

breast cancer is a major cause of mortality in women due to malignant diseases and is the most prevalent type of cancer in western countries. according to investigations which has been done in iran so far, the prevalence of disease in our country is also very high, therefore complete attention to clinical and pathological findings of this disease would be extremely essential. in this study, the...

many studies suggested that fractals could be brought in any structural anarchy, such as cancers, for diagnosis and prognosis evaluation by quantifying it and expressing it in terms of fractal geometry. in this study, we aimed to evaluate pathologic grades or breast carcinomas by fractal analysis. this cross-sectional study was performed on 60 women with breast ductal carcinoma. from all the pa...

Introduction. Occipitocervical (OC) fusion is a method for fixation of the OC junction when there instability that segment. Arnold Chiari malformation congenital disorder where cerebellar tonsils descend through foramen magnum, which can lead to corticomedullar compression and formation syrinx. While treating this condition, purpose decompression, magnum expanded, potentially harm stability jun...

gastrointestinal (gi) bleeding in pediatric patients has several causes. vascular malformation of the small bowel is a rare disease leading to pediatric gi bleeding. to our knowledge, few reports describe ultrasound and computed tomography findings of venous malformations involving the small bowel. we present a case of long-segmental and circumferential vascular malformation that led to gi blee...

the teratogenicity of cadmium exposure was studied in virgin nimri rats aged 10-13 weeks. pregnant animals were fed cadmium sulfate equivalent to doses of 1,4 and 7 mg/kg/day of cadmium by oral gavage on the day 7 of gestation. on the day 18 of gestation, fetuses were delivered and examined for external and skeletal malformations. total percent of malformed fetuses in rats treated by different ...