نتایج جستجو برای: dynamic susceptibility contrast enhanced mri
تعداد نتایج: 1285652 فیلتر نتایج به سال:
The microvascular network formed by the capillaries supplies the tissues and permits their function. It provides a considerable surface area for exchanges between blood and tissues. All pathological conditions cause changes in the microcirculation. These changes can be used as imaging biomarkers for the diagnosis of lesions and optimisation of treatment. Among the many imaging techniques develo...
Introduction The use of nanoparticles for biomedical applications has benefited from rapid progress both in the nanoscale synthesis of materials with specific optical [1] and magnetic properties [2], and in the biofunctionalization of surfaces, allowing targeting in-vivo tracking, and therapeutic action [3]. For magnetic resonance imaging (MRI), superparamagnetic nanoparticles [2] have extended...
We used dynamic MRI to evaluate the effects of monoclonal antibodies targeting brain tumor vasculature. Female athymic rats with intracerebral human tumor xenografts were untreated or treated with intetumumab, targeting α(V)-integrins, or bevacizumab, targeting vascular endothelial growth factor (n = 4-6 per group). Prior to treatment and at 1, 3, and 7 days after treatment, we performed standa...
BACKGROUND Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and...
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