Pagetoid dyskeratosis is a frequent incidental finding in various skin lesions. The patient was a 27-year-old woman who consulted for an asymptomatic hyperpigmented lesion that had arisen on the left palm 18 months earlier. Examination revealed a dark brown, hyperpigmented macule measuring 40 × 3 mm, with well-defined borders and a linear appearance (Fig. 1). Dermoscopy showed a parallel patter...

INTRODUCTION Paraneoplastic pemphigus is an autoimmune disease associated with an underlying tumor. Several cases have been reported as unusual pemphigus vulgaris, erythema multiforme, or paraneoplastic bullous disease, but the incidence of the condition is unknown. Response to treatment is generally poor, with significant morbidity and mortality. This condition is clinically characterized by s...

Varicella (chickenpox) is a highly contagious disease caused by varicella zoster virus (VZV). The primary infection results in acute varicella with fever, malaise, and a widely disseminated vesicular and itching rash, frequently solving with scars. The rash begins on the face, scalp, and trunk and occurs in crops; typically, lesions are at different stages of evolution. The oral mucous membrane...

Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype-phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the di...

Warty (follicular) dyskeratoma (WD) is a discrete nodular lesion that demonstrates the characteristic histopathologic findings of acantholysis and dyskeratosis. WDs most commonly occur on the head and neck of adults. We present a case of WD that occurred on the mons pubis of a 53-year-old woman. Only a few other cases of WDs occurring on the vulva have been reported. WD most likely represents a...

We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence ...