Thiolo thiophosphate analogues of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP) were synthesized. Inorganic thiopyrophosphate (SPP(i)) was prepared from trimethyl phosphate in four steps. The tris(tetra-n-butylammonium) salt was then used to convert isopentenyl tosylate to (S)-isopen...

1. Hoover RR, Mahon FX, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002;100:1068-1071. 2. O’Connell M, Wolfinger R. Spatial regression models, response surfaces and process optimization. J Comput Graph Statist. 1997;6:224-241. 3. Shi B, Yaremko B, Hajian G, et al. The farnesyl protein transferase inhibitor SCH66336 synergizes with ta...

Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the leaves of A. vasica using column chromatography. Vasicine acetate was obtained by acetylation of Vasicine. Vasicine acetate exhibited good zone of inhibition against bacteria: 10 mm against E. aerogenes, 10 mm against S. epidermidis, and 10 m...

The enzyme catalysing the synthesis of farnesyl pyrophosphate from dimethylallyl pyrophosphate and isopentenyl pyrophosphate, or from geranyl pyrophosphate and isopentenyl pyrophosphate, has been purified 100-fold from homogenates of pig liver. The enzyme has optimum pH 7.9 and requires Mg(2+) as activator in preference to Mn(2+); it is inhibited by iodoacetamide, N-ethylmaleimide, p-hydroxymer...

Synthesis o f carotenoids is photoregulated in m any fungi including Neurospora crassa. In order to investigate the regulatory m echanism at the enzym e level, several carotenoid m utants o f Neurospora were used to determ ine the activities o f enzym es involved in the carotenoid b io­ synthetic pathway after growth under illum ination or in darkness. Light stim ulation o f caro­ tenoid form a...

The genus Tanacetum L. belongs to the Asteraceae family and Anthemideae tribe is one of the most important medicinal plants that contains 26 species in Iran, 12 of them are endemic. This paper reports the essential oil composition of Tanacetum uniflorum (Fisch. & C.A. Mey. ex DC.) Sch.Bip. growing spontaneously in Salmas (North-West of Iran). Essentail oil extracted by water distillation and st...

the hydro-distilled volatile oils, obtained from dried e ndocarp and hulls of persian bay laurel ( laurus nobilis var. angustifolia ) from laueaceae family were analyzed by gc/ms. thirteen and twelve compounds consisting 81.6% and 89.1% of the total components were identified of the oils obtained with a yield of 3% and 1.2% (w/w) respectively. differences of some compounds between endocarp and ...

Protein isoprenylation is a lipid posttranslational modification required for the function of many proteins that share a carboxyl-terminal CAAX motif. The X residue determines which isoprenoid will be added to the cysteine. When X is a methionine or serine, the farnesyl-transferase transfers a farnesyl, and when X is a leucine or isoleucine, the geranygeranyl-transferase I, a geranylgeranyl gro...