ADAMTS1/METH1 belongs to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteins that currently comprises 18 members. Targeted inactivation of the ADAMTS1 gene results in morphological defects in the kidney, adrenal gland, and adipose tissue in addition to growth retardation and infertility in females. To gain further insight on the biology of ADAMTS1, we e...

Fibroblast growth factors (FGFs) are structurally related mitogens that can regulate the differentiation of a wide variety of cells. As a step towards elucidating the developmental roles played by one of these factors, we have used in situ hybridization methods to examine expression of the murine F gf-5 gene during embryogenesis. F gf-5 RNA was detected at seven distinct sites in the developing...

We study the problem of quadruple extensions of simple Lie algebras. We find that, adding a new simple root α+4, it is not possible to have an extended Kac-Moody algebra described by a Dynkin-Kac diagram with simple links and no loops between the dots, while it is possible if α+4 is a Borcherds imaginary simple root. We also comment on the root lattices of these new algebras. The folding proced...

We analyse the M-theoretic generalisation of the tangent space structure group after reduction of the D = 11 supergravity theory to two space-time dimensions in the context of hidden Kac–Moody symmetries. The action of the resulting infinitedimensional ‘R symmetry’ group K(E9) on certain unfaithful, finite-dimensional spinor representations inherited from K(E10) is studied. We explain in detail...

Growing environmental concerns over global warming and depleting fossil fuel reserves are compelling researchers to investigate green fuels such as alcoholic that not only show the concrete decrement in emissions but also enhance engine performance. The current study emphasizes influence of different blends gasoline on performance for an speed ranging from 1200 4400 rpm. obtained results demons...

Page e10 Obesity is a chronic multifactorial desease whose increasing prevalence is associated with several comorbidities. Diabetes, cardiovascular diseases, musculoskeletal diseases, mental health problems and even certain cancers are more common among obese patients. According to World Health Organization (WHO), obesity is one of the ten responsible for more than a third of deaths, being the ...

Correspondence Prof. Stephan Matthaei Spokesperson for the Panel of Experts Quakenbr ü ck Diabetes Centre, DDG clinical diabetes centre Department of Diabetology, Metabolism and Endocrinology at the Christliches Krankenhaus Academic Teaching Hospital of the Hannover Medical University Danziger Stra ß e10 49610 Quakenbr ü ck Tel.: + + 49 / 5431 / 15 2830 Fax: + + 49 / 5431 / 15 2831 S.Matthaei@c...

Here, we report the pattern of expression of the tetraspanin mTspan-5 at various developmental stages. Expression was first seen at E10 and remained until adulthood, with increased levels between P0 and P5. mTspan-5 showed high expression in the cortical areas and Purkinje cells throughout development. Moreover, transcripts were also detected in the developing heart, forelimbs, and hindlimbs.

Few randomized studies have compared the H1-receptor antagonists loratadine and ebastine in seasonal allergic rhinitis (SAR) patients. The objective of this study was to compare the efficacy and safety of ebastine 20 mg (E20), ebastine 10 mg (E10), loratadine 10 mg (L10), and placebo (P), once daily, in controlling symptoms of SAR over a 4-week period. This was a double-blind, placebo-controlle...