Elucidating the mechanisms of alternative splicing in the brain is a prerequisite to the understanding of the pathogenesis of major neurological diseases linked to impairment of pre-mRNA alternative splicing. The gene trinucleotide repeat-containing 4 (TNRC4) is predicted to encode a member of the CELF (CUG-BP- and ETR-3-like factors) family of RNA-binding proteins containing a 15-18-residue po...

Monobodies are binding scaffold proteins originating from a human fibronectin domain III (Fn3) scaffold that can be easily engineered with specificity and affinity. Human EphA2 (hEphA2) is an early detection marker protein for various tumors including lung, breast, and colon cancer. In this study, we isolated two hEphA2-specific monobodies (E1 and E10) by screening a yeast surface display libra...

We previously isolated a novel dodecapeptide containing a C-terminal -Arg-Phe-NH(2) sequence, SIKPSAYLPLRF-NH(2) (RFamide peptide), from the Japanese quail (Coturnix japonica) brain. This novel quail peptide was shown to be located in neurons of the paraventricular nucleus (PVN) and their terminals in the median eminence (ME), and to decrease gonadotropin release from cultured anterior pituitar...

The anterior pituitary is comprised of five major hormone-secreting cell types that differentiate during embryonic development in a temporally distinct manner. Microarrays containing 5,128 unique cDNAs expressed in the chicken neuroendocrine system were produced and used to identify genes with potential involvement in the onset of thyroid-stimulating hormone beta-subunit (TSHbeta), growth hormo...

the use of bio-ethanol as an alternative diesel engine fuel is rapidly increasing. bio-ethanol is mixed with diesel fuel at different ratios and used in ci and si engines. since vibrations have direct effects on users and engine components, for this reason analysis of vibration resulting from combustion in ci engines is very important. in this study, evaluation of vibration was performed for bo...

Some challenges for econometric research on trending time series are discussed in relation to some perceived needs of macroeconomics and macroeconomic policy making. JEL Classi...cation: C32, C53, E10

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It is shown that the neverending oscillatory behavior of the generic solution, near a cosmological singularity, of the massless bosonic sector of superstring theory can be described as a billiard motion within a simplex in nine-dimensional hyperbolic space. The Coxeter group of reflections of this billiard is discrete and is the Weyl group of the hyperbolic Kac-Moody algebra E10 (for type II) o...

E10 chick sympathetic ganglion cells display a cell contact-dependent rise in choline acetyltransferase (ChAT) specific activity over the first several days in culture. This effect can be mimicked by addition of crude membrane fractions prepared from E10 retina and adult chicken brain, but not by those from E10 brain. The effects of both cell-cell and membrane-cell contact are inhibited by the ...

In this article, the effects of heated ethanol diesel blend on emissions were investigated experimentally. Additionally, effect post-injection strategies in AVL Boost model engine, which has same characteristics as experimental engine running with ethanol-diesel emulsion fuel, was a simulation. special designed mixer, (E10) formed 10% and 2% isopropyl stirred at 40 °C. The temperature kept cons...