Sporadic breast cancer in women <40 years is uncommon in Caucasians, in contrast to a much earlier onset in Chinese Asians. However, the molecular determinants for this earlier onset are unclear. It has been reported that SNP309 in the promoter of MDM2, the negative regulator of p53, affects the onset age of cancers in females. Essentially, the G allele, rather than the T allele, has been sugge...

breast cancer within incident of one million new cases each year has become one of the most common malignancies and leading cause of death among females. this disease is comprised of about 18% of women cancers. the availability of early detection and improved treatments may decrease the mortality rates which reflected in the united states and many other western countries. breast cancer in over ...

OBJECTIVE Mutations in the BRCA1 gene confer a high risk for the development of breast or ovarian cancer. The aim of this study was to establish the frequency and spectrum of BRCA1 mutations in Czech breast or ovarian cancer families. SUBJECTS AND METHODS We have screened 28 patients with early-onset cancer and 54 patients from risk families for germ-line mutations in BRCA1. All coding exons ...

BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred population, the prevalence of BRCA1 and BRCA2 mutations in patients with breast cancer who were unselected for a family history of this disease has not been determined. METHODS Mutations in the BRCA1 a...

Ductal and lobular carcinoma in situ (CIS) accounted for 62,280 (24.5%) of all new breast cancer diagnoses in 2009. BRCA1/2 mutations confer an extremely high risk of breast cancer, and management guidelines for BRCA1/2 mutation carriers advise close follow-up, intensive screening, and consideration of prophylactic surgery to lower this risk. The limited relevant previous data are not definitiv...

Background and purpose: After lung cancer, breast cancer, among the prevalent cancers of the world is of the most widespread disease among women. It is the most common cause of mortality among women. This study aimed to analyze the results using breast cancer screening methods among women over 20 years old. Materials and methods: The present study is a cross-sectional-descriptive research. The ...

breast cancer is the most common type of cancer among women. the important key to treat the breast cancer is early detection of it because according to many pathological studies more than 80% of all abnormalities are still benign at primary stages; so in recent years, many studies and extensive research done to early detection of breast cancer with higher precision and accuracy.infra-red breast...

Objective To determine whether familial risk of cancer is limited to early onset cases. Design Nationwide prospective cohort study. Setting Nationwide Swedish Family-Cancer Database. Participants All Swedes born after 1931 and their biological parents, totalling >12.2 million individuals, including >1.1 million cases of first primary cancer. Main outcome measures Familial risks of the concordan...

background: although breast cancer imposes a considerable economic burden on high-income countries, there is limited knowledge about its economic burden in low- and middle-income countries (lmcs), including iran. in this study, we estimated the economic burden of breast cancer in iran in 2010. methods: we used the prevalence-based approach and estimated the direct and indirect costs of all brea...