UNLABELLED Fibrodysplasia ossificans progressiva formerly known as Myositis ossificans progressiva is a rare hereditary mesodermal disorder. It is characterized by congenital skeletal anomalies and progressive ectopic bone formation in connective tissue, resulting in mature ossification within soft tissues and bridging between osseous structures. It is extremely rare and has an incidence of one...

To understand the molecular pathogenesis of ossification of the posterior longitudinal ligament of the spine (OPLL), an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients to understand the molecular pathogenesis of OPLL. We identified promyelotic leukemia zinc finger (PLZF) as one of upregulated genes and tumor necrosis factor-α-s...

Case Description- The peresent case described sialocele associated with sialoliths and ectopic ossification in a 3-year-old female terrier dog.Clinical Findings- In the general examination, an enlargement fluctuate mass was seen blow the jaw around the neck. Clinical parameters (TPR) and blood test results were normal. The radiograph was showed the fluid opacity mass with some radioopaque...

There is a significant need for therapies to enhance fracture healing, especially in larger species like the horse. Traditional bone grafting techniques have limitations that may be avoided with stem cell tissue engineering strategies. While many of the early discoveries that serve as the foundation for the “stem” cells of today occurred within the last 70 years, sentinel findings by cell biolo...

To reveal the involvement of extracellular nucleotides in the ossification process in ossification of the posterior longitudinal ligament of the spine (OPLL), the mRNA expression profiles of P2 purinoceptors, mechanical stress-induced ATP release, and ATP-stimulated expression of osteogenic genes were analyzed in ligament cells derived from the spinal ligament of OPLL patients (OPLL cells) and ...

BACKGROUND Salivary mucocele is an accumulation of saliva in a single or multiloculated cavity lined by connective tissue that is contiguous to a salivary gland-duct complex and is the most common condition affecting the salivary glands in dogs. Occasionally, different types of metaplastic lesions, such as squamous and osseous metaplasia - which are rare lesions in animals - can be observed in ...

A method to classify the degree of ectopic-bone formation about the hip following total hip arthroplasty revealed that 21 per cent of 100 consecutive patients treated by total hip arthroplasty had ectopic-bone formation about the hip of various degrees when reviewed six months following the operation. Ectopic-bone formation, however, did not seem to affect the functional result as judged by the...

Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we demonstrate endothelial Yap/Taz is a novel regulator of intramembranous ossificat...

choanal polyps are a form of nasal polyps that grow toward the choana with a single stalk. septochoanal polyp is a rare entity that originates from the mucosa of the nasal septum with choanal extension. the most common site of its origin is mainly the superior aspect of the posterior portion of the nasal septum. however, metaplastic ossification is a rare event in nasal polyp and to the best of...

BACKGROUND AND PURPOSE Endochondral ossification of the otic capsule is a process that continues postnatally; hence, incomplete endochondral ossification is seen as pericochlear hypoattenuation on temporal bone CT scans of children. We determined the prevalence and extent of this entity in a large series and assessed its relation to age and underlying sensorineural hearing loss. MATERIALS AND...