Based on “similar” effectiveness, the economics of treating relapsing-remitting multiple sclerosis with fingolimod and natalizumab were studied a cost-minimization analysis (CMA) in 2012 based Swedish data. Fingolimod was cost-saving compared natalizumab. However, studies have shown difference efficacy favoring natalizumab, leading to possibility that, while more costly, it may be cost-effectiv...

To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). Methods In the construction of a decision tree model, the efficacy and safety parameters came from the results of the randomized, controlled trial conducted here, the effect parameters were derived from expert advice, and the cost parameters, such as usage ...

Expenditure on endangered species management is increasing greatly, on a global basis. Managers need tools to evaluate the performance of endangered species programmes because there will always be more demand for resources than there are available. Cost Effectiveness Analysis (CEA) is used here to evaluate the performance of the kokako (Callaeas cinerea) recovery programme. This species is bein...

PURPOSE Clinical studies suggest that carcinoembryonic antigen (CEA) is associated with metastatic progression of colon cancer. However, the biological function of CEA is not well understood. We have established an approach that allows studying of CEA function within the intact pathophysiological context of human colon cancer cells. EXPERIMENTAL DESIGN We expressed CEA-targeted ribozymes unde...

BACKGROUND Breast cancer is the most common cancer in women worldwide. Biology contributes to the early diagnosis and monitoring of breast cancer with several categories of markers such as prognostic markers (ER, PR, HER2), proliferative markers (Ki67), and tumor markers such as CEA and CA 15-3. CEA can be detected at a high concentration in serum of patients with malignant tumors. AIM The ai...

BACKGROUND The significance of carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7) expression in gastric carcinoma and precancerous lesions and its correlation with CEA expression has rarely been previously investigated. METHODS CEACAM7 and CEA expression was detected by immunohistochemistry in consecutive sections of 345 subjects with gastric carcinoma and precancerous lesion...

BACKGROUND Cost-Effectiveness Analysis (CEA) has been promoted as an important research methodology for determining the efficiency of healthcare technology and guiding medical decision-making. Our aim was to characterize the collaborative patterns of CEA conducted over the past two decades in Spain. METHODS AND FINDINGS A systematic analysis was carried out with the information obtained throu...

Multiple strategy comparisons in health technology assessment (HTA) are becoming increasingly important, with multiple alternative therapeutic actions, combinations of therapies and diagnostic and genetic testing alternatives. Comparison under uncertainty of incremental cost, effects and cost effectiveness across more than two strategies is conceptually and practically very different from that ...

Objective: A comprehensive of published randomized controlled trials (RCTs) was performed to evaluate the mid-term safety carotid artery stenting (CAS) versus endarterectomy (CEA) for both asymptomatic and stenosis. Material Methods: In this research, trails from 1994 until December 31, 2021 using ScienceDirect, Pubmed, Web Science, Sage, Ebscohost, Scopus Cochrane Central electronic databases....