Uma nova série de nove 3-fosfato-(4,4,4-trifluor-butil)-carbamatos de etila (compostos fosfatocarbamato), foram obtidos através da reação de (4,4,4-trifluor-3-hidroxibut-1-il)-etil carbamatos com oxicloreto de fósforo seguido de adição de álcoois. Os produtos foram caracterizados por espectroscopia de RMN de H, C, P e F, CG-EM e análise elementar. Todos os compostos sintetizados foram testados ...

OBJECTIVES The determination of cholinesterase activity has been commonly applied in the biomonitoring of exposure to organophosphates and carbamates and in the diagnosis of poisoning with anticholinesterase compounds. One of the groups who are at risk of pesticide intoxication are the workers engaged in the production of these chemicals. AIMS The aim of this study was to assess the effect of...

Among the pathologic hypotheses of Alzheimer’s disease (AD), cholinergic deficit and oxidative stress have been implicated as two major hallmarks. Therefore, inhibition of cholinesterase and oxidation are the two promising strategies in the development of a drug for AD. Thunbergia grandiflora leaf extract (TGEx) is used in this research to investigate its anticholinesterase and antioxidant pote...

The association of rheumatoid arthritis and Addison's disease in the same patient is very rare. In the English literature three papers reporting single cases have been found, and reference was made in two of these to three French articles dealing with the same subject (Perera and Ragan, 1950; Caughey and McCoy, 1951; Ellman and Cudkowicz, 1952). In these cases the onset ofrheumatoid arthritis p...

Cyclic tetrapeptide and depsipeptide natural products have proven useful as biological probes and drug candidates due to their potent activities as histone deacetylase (HDAC) inhibitors. Here, we present the syntheses of a class of cyclic tetrapeptide HDAC inhibitors, the azumamides, by a concise route in which the key step in preparation of the noncanonical disubstituted β-amino acid building ...

Tetrahydropyranyl (Thp) is recognized as a useful protecting group for alcohols in organic synthesis. It has several advantages, including low cost, ease of introduction, general stability to most non-acidic reagents, it confers good solubility, and the ease with which it can be removed if the functional group it protects requires manipulation. However, little attention has been paid to Thp in ...

One of the major obstacles for knowledge management remains MultiWord Terminology (MWT). This paper explores the difficulties that arise and describes real world solutions implemented as part of the Parmenides project. Parmenides is being built as an integrated knowledge management package that combines information, MWT and ontology extraction methods in a semi-automated framework. The focus of...

The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported. The intramolecular allylic substitution reaction of a readily available joint urea-type substrate enables the facile preparation of both diastereomers in high yields. The practical application of this approach is demonstrate...

organophosphate (ops) compounds are widely used in intensive agriculture to improve production, protect crops and control diseases vectors. the main mechanism of toxicity of ops is the inhibition of the cholinesterase enzymes. in this study the acetylcholinestrase (ache), butyrylcholinesterase (bche) and specific acetylcholinestrase (sache) activities as potential biomarkers of exposure to ops ...

Alzheimer hastalığı (AD), beyinde asetilkolin üreten veya kullanan kolinerjik hücrelerin yıkımı kaybından kaynaklanmaktadır. Bundan dolayı, AD için ana tedavi stratejisi beyindeki seviyesini arttırmaktır.
 Bu çalışmada, kolinesteraz inhibitörleri olarak yeni tiyazol-hidrazinil türevlerinin sentezi gerçekleştirilmiştir. Sentezlenen bileşiklerin yapısı 1H-NMR ve 13C-NMR verileri ile aydınlat...