BACKGROUND AND PURPOSE Limited data exists regarding the relationship between left ventricular systolic dysfunction (LVSD) and heart failure (HF) symptoms and embolic risk among patients with atrial fibrillation. METHODS Participants in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE) trials with HF, but not randomized to oral anticoagulatio...

BACKGROUND AND PURPOSE Stent retriever-assisted thrombectomy promotes high recanalization rates in acute ischemic stroke. Nevertheless, complications and failures occur in more than 10% of procedures; hence, there is a need for further investigation. MATERIALS AND METHODS A total of 144 patients with ischemic stroke presenting with large-vessel occlusion were prospectively included. Patients ...

M anipulation of atherosclerotic lesions with wires, cath-eters, balloons, stents, and other intravascular devices during invasive procedures releases atherosclerotic plaque, resulting in distal embolization. This plaque debris leads to no or slow flow as a result of a multitude of factors, including mechanical obstruction of macrovascular and microvascu-lar channels, local platelet adhesion, p...

authors and five references. They should not have tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Only some letters will be published. Authors of those selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed i...

The clinical and postmortem data from a 14-year-old girl who had transient embolic aortoarteritis are presented. This disease was first described in 1974 by Peiris and Wickremaslnghe in Hindu patients and is characterized by repetitive embolic occlusion of infraand extracranial vessels of the brain, originating from focal thrombotlc lesions in the aorta and its primary branches. The main histop...

BACKGROUND AND PURPOSE The clinical application of Doppler detection of circulating cerebral emboli will depend on a reliable automated system of embolic signal detection; such a system is not currently available. Previous studies have shown that frequency filtering increases the ratio of embolic signal to background signal intensity and that the incorporation of such an approach into an offlin...

 We report a case of Nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. This case is unique because she developed compartment syndrome in her left calf far from her injection site. Her toe’s tips gangrened in the course of her ailment. We hypothesized that the compartment syndrome might be produced by a probable intra-arteri...