introduction: in iran, thousands of young individuals become victims of head injury annually. head injury can damage neuronal cells which may in turn complicate the recovery of the patients. also, the increase of iron in cerebrospinal fluid (csf) following head injury may contribute to the hypoxic-ischemia brain damage by catalyzing the formation of free radicals (harber-weiss rection). the obj...

abstractbackgroundline of treatment for management of hydrocephalus despite available new techniques andsystems of shunting. associated complications should be recognized and managed properly,but the most recognized complications are shunt obstruction which its prevalencethrough surgical approach is discussed here. two approaches (frontal and parietal) are usedto insert ventriculoperitoneal shu...

Osteoclasts are induced by macrophage colony-stimulating factor-1 (CSF-1) and receptor activator of nuclear factor-?B (RANK) ligand (RANKL). Monocyte/macrophage lineages thought to be osteoclast precursors; however, such cells have not been fully characterized owing a lack tools for their identification. Osteoclast precursors express (CSF-1R) RANK. However, the capacity conventional methods usi...

The aim of this study was to determine whether anthocyanins and their phase II metabolites permeate the blood-cerebrospinal fluid barrier (B-CSF-B) sheep profile these compounds in biofluids after chokeberry intraruminal administration. Anthocyanins were analyzed using micro-HPLC-MS/MS. After administration, absorbed occurred body fluids mainly form methylated, glucuronidated, sulfated derivati...

Human granulocyte-colony stimulating factor (hG-CSF) cDNA was expressed in the methylotrophic yeast Pichia pastoris under the control of the alcohol oxidase (AOX1) promoter. An expression vector for hG-CSF secretion was constructed using vector pPIC9. Higher levels of hG-CSF was obtained using a P. pastoris Mut+ (methanol utilization fast) phenotype. The effects of environmental factors such as...

Introduction: Evaluation of the cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (CNS) infection. Although normal values are well established for CSF cell counts and protein and glucose contents in children and adults, this is not the case for neonates. The purpose of this st...