Complete DiGeorge syndrome is a fatal congenital disorder characterized by athymia, hypoparathyroidism, and heart defects. Less than half of patients are 22q11 hemizygous. The goal of this study was to assess if immune suppression followed by postnatal thymus transplantation would lead to T-cell function in 6 infant patients who had host T cells at the time of transplantation. All infants had f...

The liver is a unique lymphoid organ whose microenvironment is biased towards tolerance induction. We previously found that a proportion of CD4(+) autoreactive recent thymic emigrants (RTEs) retained in the liver after thymic egress and acquired IL-10 producing capability. To investigate the tolerance of these liver persisting CD4(+) RTEs in more detail and to study the liver stromal cell types...

OBJECTIVE A growing number of studies have examined the "immigrant paradox" with respect to the use of licit and illicit substances in the United States. However, there remains a need for a comprehensive examination of the multigenerational and global links between immigration and substance use disorders among adults in the United States. METHOD The present study, using data from the National...

Macrophage tropic HIV-1 is predominant during the initial viremia after person to person transmission of HIV-1 (Zhu, T., H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho. 1993. Science. 261:1179-1181.), and this selection may occur during virus entry and carriage to the lymphoid tissue. Human skin explants were used to model HIV-1 selection that may occur at the skin or mucosal surface....

The Healthy Immigrant Paradox found in the literature by comparing health of immigrants with that natives destination country, may suffer from serious social and cultural biases. Our study avoids such biases utilizing an origin–destination framework, which compares emigrants compatriots who remain origin country. Isolating effects can best gauge migration living abroad on migrants. We both phys...

Abstract Moving–particularly to a new country–is fraught with risks as migrants leave familiar legal frameworks and cultural institutions behind them. To date, little is known about the psychological determinants of international migration. This chapter helps fill this gap by analysing data from first wave German Emigration Remigration Panel Study (GERPS) in combination on non-mobile individual...

One of the most important problems in study йmigrй communities is problem social adaptation emigrants to conditions new sociocultural environment. This issue analysed both at level emigration as a whole or regional emigrant colony and an individual family individual. article devoted analysis “clan” model emigrants’ proposed by author with reference Far Eastern Yankovsky family, who emigrated Ko...