INTRODUCTION Severe oedematous forms of Buruli ulcer (BU) often result in extensive tissue destruction, even with the institution of appropriate antibiotic treatment, leading to reconstructive surgery and long-term disability. We report a case of a patient with severe oedematous BU, which describes for the first time the pre-emptive use of prednisolone therapy commenced at the time of antibioti...

This paper examines strategic investment games between two firms that compete for optimal entry in a project that generates uncertain revenue flows. Under asymmetry on both the sunk cost of investment and revenue flows of the two competing firms, we investigate the value of real investment options and strategic interaction of investment decisions. Compared to earlier models that only allow for ...

background: blood neutrophil to lymphocyte ratio (nlr) and mean platelet volume (mpv) both have been used as a simple marker of inflammation in many disorders. here, we aimed to investigate the relationship between nlr, mpv, and familial mediterranean fever (fmf). materials and methods: in this retrospective study, the fi les of fmf patients in pediatric rheumatology outpatient clinic were revi...

Future vehicle localisation technologies enable major enhancements of dynamics control. This study proposes a novel stability control paradigm, based on pre-emptive that considers the curvature profile expected path ahead in computation reference direct yaw moment and braking action. The additional information allows trail control, which slows down if predicted speed current torque demand is de...

CONTEXT Oral activated charcoal (AC) for toxin absorption should be applied as soon as possible. Extra-hospital AC-application on site by medical laypersons with pre-emptive obtained AC may save time, but may be inferior to AC-application by medical professionals. OBJECTIVE 1) Availability and incidence of pre-emptive stockpiling of AC on site in the German region Bavaria 2) time saved by AC-...

abstract background: postoperative pain is an important surgical problem. recent studies in pain pathophysiology have led to the hypothesis that with perioperative administration of analgesics (pre-emptive analgesia) it may be possible to prevent or reduce postoperative pain. this study was planned to investigate the efficacy of pre-emptive analgesia on postoperative pain after major gynecologi...