PURPOSE Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles (NPs) using PLGA polymer and to compare the effectiveness of prepared nanoparticles with untreated AZI solution. METHODS AZI NPs were prepared by Modified Quasi-Emulsion Solve...

a box-behnken design with three replicates was used for preparation and evaluation of eudragit vancomycin (vcm) nanoparticles prepared by double emulsion. the purpose of this work was to optimize vcm nanoparticles to improve the physicochemical properties. nanoparticles were formed by using w1/o/w2 double-emulsion solvent evaporation method using eudragit rs as a retardant material. full factor...

The purpose of this research work was to obtain directly compressible enteric recrystallized agglomerates of erythromycin containing enteric polymers by emulsion solvent diffusion technique. Selected solvent for the process includes the best solvent (ethyl alcohol), non-solvent (distilled water) and bridging liquid (chloroform) according to their solubility in different organic solvent. The dif...

Purpose: To study the effect of some factors on the size of finasteride nano-emulsion by chemometric approach which could predict the size of nano-emulsion droplets under different conditions. Methods: Nano-emulsions were prepared using spontaneous emulsification method which occurs when organic and aqueous phases are mixed. The organic phase was a homogeneous solution of oil (finasteride as a ...

We sought to determine if the solvent in the formulation of etomidate is responsible for haemolysis in patients. In a randomized, prospective, double-blind study of 49 patients undergoing otolaryngological surgery, patients received etomidate dissolved in propylene glycol or in lipid emulsion. Concentrations of free haemoglobin and haptoglobin were measured before and for up to 360 min after in...