AIM To validate the first non-invasive measurements of volumetric ophthalmic artery blood flow in humans. METHODS The ophthalmic arteries of healthy normal adults were examined by Advanced Technology Laboratories (ATL, a subsidiary of Phillips Medical Systems Inc) high definition imaging (HDI) 5000 colour Doppler imaging ultrasound with a 5-12 MHZ probe. A group of 14 subjects for experiment ...

Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and ...

In patients with technically adequate selective coronary arteriograms and left , ventriculograms, a scoring system was used to grade the severity of coronary obstruction from 0 (no disease) to 15 (total obstruction of all three major coronary arteries). The median score in 75 consecutive cases was 10. Three hemdynamic measurements were examined in these patients; left ventricular end-diastolic ...

BACKGROUND Measure of blood flow velocity in retrobulbar vessels is performed to determine the severity of ophthalmic pathologies as glaucoma. In children, this measure is usually performed under general anaesthesia. Sevoflurane is known to not modify cerebral blow flow velocities. However, its effect on retrobulbar circulation is not known. This study was designed to evaluate the effect of sev...

BACKGROUND Type 2 diabetes mellitus (DM2) may induce epicardial coronary artery diseases and left ventricular myocardial damaging as well. Left ventricular dysfunction was found in DM2. In this research, we compared the left ventricular dysfunction of coronary artery disease (CAD) patients with and without type 2 diabetes mellitus as well as normal controls using the volume-time curve of cardia...

Whereas improvement in diastolic function indexes in response to therapeutic interventions has been attributed to a beneficial effect of the intervention, measurements of diastolic function appear to be influenced by changes in loading conditions, heart rate and sympathetic tone. To determine the effect of body position and short-term pharmacologic intervention on radionuclide angiographically ...

Methods A Siemens scanner (Avanto, 1.5T) was used to study 13 patients (mean age 65 ± 9, 4 females and 9 males) with persistent AF before and 3 months after ablation therapy. Images of the LA were acquired in the two-chamber and four-chamber orientation using a breath-hold ECG-gated steady state free precession cine sequence. Biplane arealength method was used to measure the LA end-systolic (ES...

BACKGROUND Vascular insufficiency has been reported to be a cause of normal tension glaucoma (NTG). The aim of this study was to compare ocular perfusion pressure (OPP) and ophthalmic artery flow (OAF) between patients with NTG and those without glaucoma. METHODS We considered one eye each from 31 NTG and 15 non-glaucoma control patients. Blood pressure and intraocular pressure (IOP) were mea...

BACKGROUND Myocardial perfusion scintigraphy (MPS) is a clinically useful noninvasive imaging modality for diagnosing patients with suspected coronary artery disease. By utilizing gated MPS, the end diastolic volume (EDV) and end systolic volume (ESV) can be measured and the ejection fraction (EF) calculated, which gives incremental prognostic value compared with assessment of perfusion only. T...