infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...

Chick viability is known to be an important factor determining profitability of the poultry industry. Chick embryo tissues contain a high proportion of highly polyunsaturated fatty acids in the lipid fraction and therefore need antioxidant defence. The antioxidant system of the developing embryo and newly hatched chick includes the antioxidant enzymes (superoxide dismutase, glutathione peroxida...

Interferon (IFN)-gamma facilitates cellular immune response, in part, by inducing the expression of major histocompatibility complex class II (MHC-II) molecules. We demonstrate that IFN-gamma induces the expression of HLA-DRA in vascular endothelial cells via mechanisms involving reactive oxygen species. IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants su...

BACKGROUND The endogenous antioxidant system of the skin scavenges reactive oxygen species and combats ultraviolet induced oxidative skin damage. Supporting this cutaneous defense system with topical or oral antioxidants may provide a successful strategy for the treatment and prevention of skin cancer. OBJECTIVE Review evidence regarding treatment and prevention of melanoma and nonmelanoma sk...

This article reviews oxidative stress as one of the mechanisms impairing functions cells, organs, and tissues. Aging is associated with reductions in activities enzymes antioxidant system. Reactive oxygen species formed oxidant damage DNA, RNA, proteins, lipids, leading to cell apoptosis. Neurodegenerative changes can develop conditions mitochondrial dysfunction. A potential direction treatment...

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly a...

Antioxidants refer to the molecules that react with oxy radicals not only to delay their function, but also to neutralize them and subsequently reduce oxidative stress and protect us from diseases state. Despite our own endogenous response, several factors contribute to diminish our self-defense mechanism resulting in loss of control in preventing ourselves from free radical damage. Antioxidant...

Intensive oxidative processes occuring in human organism lead to formation of oxygen reactive forms, which can damage systemic cells and tissues. It is shown, that body endogenous protective system can be supported in that case by natural antioxidant compounds provided from food. The assessment of food products as the potential sources of antioxidants was performed, taking into consideration th...

The requirement for antioxidant nutrients depends on a person's exposure to endogenous and exogenous reactive oxygen species. Since cigarette smoking results in an increased cumulative exposure to reactive oxygen species from both sources, it would seem cigarette smokers might have an increased requirement for antioxidant nutrients. This review examines available evidence of ascorbic acid suppl...