A retrospective review was done to evaluate the importance of degenerative endometrial debris accompanied with benign-looking endometrial cells in Papanicolaou (Pap) smears. In total, 306 patients were divided into 2 groups according to the absence (group 1) or presence (group 2) of endometrial debris. Eighty-one (26.5%) patients received histologic follow-up. The biopsy rate for premenopausal ...

Background: Endometriosis is the presence of a functional endometrial tissue outside the uterine cavity and defines as cancer like model. Noscapine is a safe cough suppressant which has been introduced as cancer suppressor. The aim of this study was to investigate the in vitro effect of noscapine on human endometriotic epithelial cells. Materials and Methods: Human endometriotic biopsies (n=7) ...

Background Endometrial cancer (EC) is a hormone-related carcinoma with increased morbidity among female patients of all backgrounds. The immune microenvironment EC uncertain. Materials and Methods 102 were recruited in the present study. 90 postoperative specimens from analyzed by immunohistochemistry. leukocyte landscape endometrial was mapped using high-dimensional single-cell profiling (CyTO...

Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It of great significance to explore new targets for improving prognosis endometrial cancer. Chikusetsusaponin Iva (CHI) a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are un...

Accumulating evidence shows that peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is involved in the progression of hormone-related cancers, and there may exist an association between estrogen and PGC-1α. Notably, emerging evidence has led to considerable interest in the role of PGC-1α in endometrial cancer development. However, whether the synergism exists between PGC-1...

Endometrial cancer is the most common gynecological cancer but there is no economically justified screening method. Although we can detect endometrial cells in the sample using PAP test, many studies show low sensitivity and positive predictive value of PAP test for the diagnosis of endometrial cancer. The goal of this research was to determine significance of PAP test for the diagnostics of en...

The objectives of this study were to explore whether heparin-binding proteins, separated by fast protein liquid chromatography from boar seminal plasma influence the release of prostaglandins F2α, (PGF2α), E2 (PGE2) and interleukin-6 (IL-6) by porcine endometrial and cervical cells and even bovine endometrial cells. In Experiment I, we showed that release of PGF2α by endometrial epithelial, end...

To evaluate the associations among immune cells (T-cells, B-cells, Macrophages and NK cells) in human endometrium during mid-luteal phase of menstrual cycle. Endometrial biopsies were obtained from 116 women (7 days after LH surge) natural cycles. The presence CD3-positive (T-cells), CD4-positive (T-helpers), CD8-positive (T-killers), CD14-positive (Macrophages), CD68-positive CD56-positive (NK...

Background: Endometriosis is a benign hormone-dependent disease in women of reproductive age. There is no cure for eradicating the disease and there is need for new drugs. The aim of this study was to investigate the in vitro effect of noscapine as inducer of cell death on endometriotic stromal cells in patient's endometriosis in vitro. Materials and Methods: Endometrial biopsies from pati...

The endometrium is central to mammalian fertility. The endometrial stromal cells are very dynamic, growing and differentiating throughout the estrous cycle and pregnancy. In humans, stromal cells appear to have progenitor or stem cell capabilities and the cells can even differentiate into bone. It is not clear whether bovine endometrial stromal cells exhibit a similar phenotypic plasticity. So,...