Microarray technology has broadened the insight into many research fields allowing scientists to analyse the expression of many genes in quick and efficient experiments aimed at translating these findings into clinical applications. In reproductive medicine, researchers have exploited microarrays to increase understanding of the molecular mechanisms involved in endometrial receptivity and how a...

Aim: to evaluate the expression of estrogen (ER) and progesterone (PR) receptors in endometrium during "implantation window" women with a history reproductive dysfunction different endometrial thickness. Materials Methods. A prospective single-center cohort comparative study was conducted. The main group included patients hypoplastic (< 7 mm according ultrasound data on preovulatory days) (n...

BACKGROUND The endometrium is a dynamic tissue whose changes are driven by the ovarian steroidal hormones. Its main function is to provide an adequate substrate for embryo implantation. Using microarray technology, several reports have provided the gene expression patterns of human endometrial tissue during the window of implantation. However it is required that biological connections be made a...

Successful implantation depends both on the quality of the embryo and on the endometrial receptivity. The latter depends on progesterone-induced changes in gene expression, a process that has been characterized by microarray analysis. One of the genes whose transcription appears to be enhanced during the receptive period is monoamine oxidase A (MAO-A). Our first objective was to confirm the inc...

The success of reproduction, although gradually increasing over the years, many couples also had been left frustrated following repeated failed attempts. Implantation of the embryo, can only take place in a receptive uterus and inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. Endometrial receptivity can be reduced by morphological and/or molec...

BACKGROUND To determine the effect of higher progesterone (P) level on endometrial receptivity. METHODS This was a prospective analysis conducted in the Reproductive Medical Center of Peking University Third Hospital. All patients received IVF treatment and canceled embryo transfer in the same cycle and were divided into group 1 (normal P; 7 patients) and group 2 (elevated P; 12 patients). En...

BACKGROUND The HOXA10 homeobox gene controls embryonic uterine development and adult endometrial receptivity. The three-amino-acid loop extension (TALE) family homeobox genes like myeloid ecotropic viral integration site 1 (MEIS) provide enhanced target gene activation and specificity in HOX-regulated cellular processes by acting as HOX cofactors. METHODS AND RESULTS Analysis of an Affymetrix...