BACKGROUND Uterine or endocervical biopsies that contain endometrioid adenocarcinoma with widespread squamous metaplasia are usually of endometrial origin. The presence of squamous metaplasia is said to be helpful in distinguishing endocervical from endometrial adenocarcinomas in small biopsy samples. CASE PRESENTATION A 51-year-old woman presented with post-coital and post-menopausal bleedin...

in order to compare the clinical efficacy, safety, success rate and probable complications of rollerball ablation with cutting loop endometrial resection in the treatment of menorrhagia, eighty-three women in reproductive age suffering from menorrhagia who did not respond to medication were treated in a randomized study comparing cutting loop endometrial resection with hysteroscopic rollerball ...

STUDY OBJECTIVE To determine whether tubal ligation is a risk factor for future hysterectomy after second-generation endometrial ablation. DESIGN Retrospective chart review (Canadian Task Force classification II-3). SETTING Resident-run clinic and private office in a community setting. PATIENTS Five hundred eighty-seven patients who underwent endometrial ablation. INTERVENTIONS Patients...

AIMS Mismatch repair gene malfunction occurs early in the carcinogenesis of hereditary non-polyposis colorectal cancers (HNPCCs), leading to an accelerated accumulation of mutations and possibly to change in expression of cell cycle proteins. There is strong evidence that tumorigenesis in HNPCCs differs from sporadic ones. HNPCC-related endometrial cancers are less well studied. Our aim was to ...

in order to assess the efficacy of hysteroscopic endometrial ablation and factors which are important in it's success, a prospective, randomized study was performed in shiraz university hospitals between sep. 1995 to feb. 1998. 50 patients with chief complaints of menorrhagia that were in reproductive age (25- 50 years) and had shown no response to medication and d&c; underwent endometrial...

Genital Chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (UGT) damage. Consistent with this presentation, type 2 innate and TH2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the UGT of Chlamydia-infected women. Primary C. trachomatis infection of mice also causes no genital pat...

PTEN acts as a tumor suppressor primarily by antagonizing the PI3K/AKT signaling pathway. PTEN is frequently mutated in human cancers; however, in type II endometrial cancers its mutation rate is very low. Overexpression of TGF-β1 and its receptors has been reported to correlate with metastasis of human cancers and reduced survival rates. Although TGF-β1 has been shown to regulate PTEN expressi...

The histological appearances in 114 endometrial curettings from cases of dysfunctional bleeding have been analysed quantitatively by the method of Dunnill and Whitehead (1972) and Risdon and Keeling (1974). As applied to this type of specimen, the technique provides indices of both tubular volume and tubular surface to volume ratio. The histological diagnosis of endometrial hyperplasia is made ...

BACKGROUND To empirically evaluate bias in estimation of accuracy associated with delay in verification of diagnosis among studies evaluating tests for predicting endometrial hyperplasia. METHODS Systematic reviews of all published research on accuracy of miniature endometrial biopsy and endometrial ultrasonography for diagnosing endometrial hyperplasia identified 27 test accuracy studies (2,...