Melanoma is a highly aggressive kind of cancer with very poor prognosis. v-Raf murine sarcoma viral oncogene homolog B1 inhibitor vemurafenib has indeed harvested substantial clinical benefits. Nevertheless, its drug resistance also hampered scientists’ efforts towards successful melanoma treatment. In this study, we used data derived from the gene expression omnibus database to analyze effect ...

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems. Sjögren's syndrome (SS) may be primary SS (pSS) or occur together with other diseases, including SLE. This study aimed to explore the shared gene signatures in SLE and pSS. Methods Gene expression data sets of (GSE50772 GSE81622) pSS (GSE84844 GSE48378) were obtained analyzed for di...

BACKGROUND/AIMS Ischemia-reperfusion (IR) injury in the kidney is a major cause of acute kidney injury in humans. However, the molecular mechanisms responsible for the progression of kidney IR injury still need to be explored. In this study, we aimed to explore the underlying genes and pathways associated with kidney IR injury. METHODS Gene microarray of GSE27274 was downloaded from the Gene ...

Background: Accumulating reports suggest that the biological effects of low- and high- dose ionizing radiation (LDIR and HDIR) are qualitatively different and might cause different effects in human skin. Materials and Methods: To better understand the potential risks of LDIR, we analyzed three cDNA microarray datasets from the Gene Expression Omnibus database. Results: A pathway analysis showed...

Background: Camel milk can treat diabetes, but the exact anti-diabetes components of camel are still unclear. It is not clear whether exosomes regulate glucose metabolism. Therefore, aim this study was to determine promote consumption in L6 cells. Methods: were isolated by ultracentrifugation and identified transmission electron microscopy (TEM). Cell Counting Kit-8(CCK-8) assay used detect eff...

With the increasing development and use of ontologies in the biomedical domain, opportunities for their utilization in applications and workflows are being created. In this paper, we discuss how the Ontology for Biomedical Investigations (OBI) can be enriched to provide for annotation of Web services. The methodology includes designing ontology analysis diagrams for Web services and analyzing t...

Patch budding (bud grafting) is a commonly used method for pecan reproduction; however, the grafting survival rate varies with cultivars. Clarifying underlying mechanisms of successful pivotal graft technique improvement. Here, weighted gene co-expression network analysis (WGCNA) was conducted to dissect key pathways and genes related pecan. Based on transcriptome data two contrasting cultivars...

Existing data-centric methods for protein science generally cannot sufficiently capture and leverage biology knowledge, which may be crucial many tasks. To facilitate research in this field, we create ProteinKG65, a knowledge graph science. Using gene ontology Uniprot base as basis, transform integrate various kinds of with aligned descriptions sequences, respectively, to GO terms entities. Pro...

PURPOSE This study aimed to explore the molecular mechanisms associated with bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) in patients with multiple myeloma (MM). METHODS The gene expression profile GSE7116 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) from eleven patients with ONJ resulting from MM treated with BPs (ONJBPs) and t...