Shiga toxin-producing Escherichia coli (STEC) strains are a common cause of both sporadic infection and outbreaks of enteric disease in humans. Here, we present draft genome sequences of 11 STEC strains of different serotypes (O145, O121, O26, O177, and O-type unknown), that have been isolated from patients with enteric disease of various degrees of severity, in the years 2001 to 2014 at St. Ol...

Enteric fever is a disease of developing countries associated with poor public health and low socio-economic indices. Cases of enteric fever occurring in travelers returning to the United States and the UK suggest that it is present across the developing world but that the Indian subcontinent represents a hotspot of disease activity. The best figures available for the global burden of enteric f...

Worldwide, enteric infections are the second commonest cause of disease burden due to all infectious diseases. It is estimated that they are responsible for 1.3 million deaths per year, mostly in children below 5 years of age in the developing world. Enteric infections are caused by a gamut of bacterial, viral and parasitic agents. These include viruses (rotaviruses, enteric adenoviruses, astro...

on Enteric Fever in the European Army of Madras," it is stated that " the rarity or absence of enteric fever among other classes of Europeans in India is also a fact of great importance." Death announcements in the public papers from typhoid among the civil population are by no means unusual, and, judging from my own experience, gained in civil practice, I can confidently state that the disease...

The overall surveillance of enteric diseases in Ontario currently relies on the reporting of disease events by local public-health units to a centralized information system known as RDIS (Reportable Diseases Information System). Outbreak occurrences of enteric disease are reported and documented in the outbreak module of RDIS. Sporadic cases are reported separately using a case-by-case reportin...

Although the global climate is changing at an unprecedented rate, links between weather and infectious disease have received little attention in high income countries. The "El Niño Southern Oscillation" (ENSO) occurs irregularly and is associated with changing temperature and precipitation patterns. We studied the impact of ENSO on infectious diseases in four census regions in the United States...

We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. Enteric neurons and glia are present at birth in the colon of erbB2/nestin-Cre...

Intestinal bacteria aid host health and limit bacterial pathogen colonization. However, the influence of bacteria on enteric viruses is largely unknown. We depleted the intestinal microbiota of mice with antibiotics before inoculation with poliovirus, an enteric virus. Antibiotic-treated mice were less susceptible to poliovirus disease and supported minimal viral replication in the intestine. E...

Enterotoxigenic Bacteroides fragilis was isolated from stool specimens of 8 of 44 diarrheic individuals (ages, 4 months to 69 years). The individuals had watery diarrhea and intestinal cramping; and infants had hyperthermia, vomiting, and blood in the stools. No recognized enteric pathogens were detected in seven of the eight diarrheic individuals positive for enterotoxigenic B. fragilis. The b...

adenoviruses are one of the most important etiological agents of serious gastroenteritis among infants and young children. fecal specimens from patients with an acute gastroenteritis were evaluated for the presence of adenovirus (ad40, 41) from april 2002 to february 2004. during the study, 1052 samples were collected from children under the age of 5 years in six educational and therapeutic ped...