Hepatitis C virus can lead to chronic infection, cirrhosis and hepatocellular carcinoma. With more than 170 million people infected worldwide, eradication remains a challenge even with the revolutionary current direct antiviral agents (DAAs). The risk of resistance, the safety profile in some populations, the genotype specificity and the high price of current DAAs explain why there is still int...

Glucagon-like peptide-1 7-36 amide (GLP-1) has been postulated to be the primary hormonal mediator of the entero-insular axis but evidence has been indirect. The discovery of exendin (9-39), a GLP-1 receptor antagonist, allowed this to be further investigated. The IC50 for GLP-1 receptor binding, using RIN 5AH beta-cell membranes, was found to be 0.36 nmol/l for GLP-1 and 3.44 nmol/l for exendi...

BACKGROUND We reviewed our experience with patients presenting with trauma and peritonitis who underwent an open abdomen (OA) procedure, and compared outcomes between Negative Pressure Wound Therapy (NPWT) and a modified Barker Vacuum Pack (mBVP) technique. METHODS In this descriptive study, we retrospectively analyzed data regarding all patients who underwent OA for intra-abdominal sepsis or...

Introducción: Los estomas flotantes se definen como un estoma que no esta fijado a la piel de pared abdominal, técnica ha descrito en cirugía para fistulas entero atmosféricas y control daños.Caso Clínico: Presentamos reporte caso manejo absceso paraostomal paciente con antecedente laparotomía por abdomen agudo, lo decide uso terapia presión negativa asociada flotante, demostrando su utilidad e...